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Cholecystoduodenal fistula caused by aggressive mucinous gallbladder carcinoma with a porcelain gallbladder

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Abstract

Cholecystoduodenal fistula secondary to gallbladder carcinoma (GBC) is extremely rare and develops when the tumor penetrates into the adjacent duodenum. A porcelain gallbladder is also a very rare entity that involves the calcification of the gallbladder wall and can be associated with the development of GBC. Herein, we report an unusual case of a patient with cholecystoduodenal fistula, which has been caused by aggressive mucinous gallbladder carcinoma with a porcelain gallbladder. A 68-year-old man was referred to our department due to significant accumulation near the neck of the gallbladder detected by FDG positron emission tomography/computed tomography (PET/CT), which was performed as a check-up of postpneumonectomy for lung cancer. Abdominal contrast CT and magnetic resonance imaging revealed porcelain-like circumferential calcification of the gallbladder wall and a mass in the region detected by FDG PET/CT. Furthermore, upper endoscopy revealed a submucosal tumor with apical ulceration in the posterior wall of the duodenal bulb. Histopathological examination of its biopsy specimen rendered a diagnosis of adenocarcinoma. The patient was preoperatively diagnosed with either gallbladder cancer or duodenal cancer, and subtotal stomach-preserving pancreatoduodenectomy and radical cholecystectomy with gallbladder bed resection were performed. The resected gallbladder revealed a porcelain gallbladder, which formed the cholecystoduodenal fistula. These specimens were histopathologically diagnosed as mucinous adenocarcinoma of the gallbladder with an abundant mucin production.

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Acknowledgements

The authors state that they have no conflict of interest (COI).

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All authors disclosed no financial relationships relevant to this publication.

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Authors and Affiliations

  1. Division of Gastroenterology, Shinko Hospital, 1-4-47 Wakihama-cho, Chuo-ku, Kobe, Hyogo, 651-0072, Japan

    Yoshihide Matsumoto, Eri Senda, Seiji Shio & Hajime Yamada

  2. Department of Gastroenterological Surgery, Shinko Hospital, Kobe, Hyogo, Japan

    Koji Fujimoto & Eisei Mitsuoka

  3. Department of Pathology, Shinko Hospital, Kobe, Hyogo, Japan

    Kazuhito Ichikawa

Authors
  1. Yoshihide Matsumoto
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  2. Koji Fujimoto
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  3. Eisei Mitsuoka
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  4. Eri Senda
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  5. Seiji Shio
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  6. Kazuhito Ichikawa
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  7. Hajime Yamada
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Contributions

YM diagnosed and drafted this article. KF treated and supervised the process of drafting this article. EM treated this case. ES, SS, and KI diagnosed this case. HY supervised the process of drafting this article.

Corresponding author

Correspondence to Yoshihide Matsumoto.

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All procedures followed have been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

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Informed consent was obtained from all patients for being included in the study.

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Matsumoto, Y., Fujimoto, K., Mitsuoka, E. et al. Cholecystoduodenal fistula caused by aggressive mucinous gallbladder carcinoma with a porcelain gallbladder. Clin J Gastroenterol 12, 460–465 (2019). https://doi.org/10.1007/s12328-019-00969-9

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  • DOI: https://doi.org/10.1007/s12328-019-00969-9

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