Abstract
We report a 54-year-old female patient with myelodysplastic syndrome (MDS) associated with trisomy 8, who had multiple colonic ulcers. The patient had been diagnosed as having MDS of refractory cytopenia with trisomy 8 10 years previously. She underwent colonoscopy for abdominal pain, which revealed severe circumferential stenosis with multiple ulcers in the ileocecal region and a discrete excavating ulcer in the transverse colon. The patient had been free from any dermatological, oral, genital or ocular symptoms suggestive of Behçet’s disease (BD). A diagnosis of multiple colonic ulcers associated with MDS with trisomy 8 was thus suggested. Follow-up colonoscopies 5 and 6 years later revealed progression of the ileocecal stenosis to a circumferential ulcer, while the ulcer in the transverse colon had not changed. Because our patient lacked extraintestinal symptoms of BD, trisomy 8 was presumed to be responsible for her colonic ulcers.
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Shunichi Yanai, Shotaro Nakamura, Keisuke Kawasaki, Shigeki Ito, Tamotsu Sugai and Takayuki Matsumoto declare that they have no conflict of interest.
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All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institution and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).
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Informed consent was obtained from this patient for being included in the study.
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Yanai, S., Nakamura, S., Kawasaki, K. et al. Multiple colonic ulcers associated with trisomy 8: serial changes in colonoscopic findings. Clin J Gastroenterol 9, 298–301 (2016). https://doi.org/10.1007/s12328-016-0671-6
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DOI: https://doi.org/10.1007/s12328-016-0671-6