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Clear cell sarcoma of the esophagus: report of a case

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Abstract

We report a rare case of clear cell sarcoma of the esophagus and review the literature regarding clear cell sarcomas of the gastrointestinal tract. A 57-year-old male was admitted with dysphagia during swallowing. Preoperative imaging studies, including upper gastrointestinal endoscopy and endoscopic ultrasonography, showed that the tumor was located between the mucosa and the muscularis propria of the lower esophagus. We performed subtotal esophagectomy with gastric tube reconstruction. Pathological findings of the tumor showed mixed spindle cells and oval cells. Immunohistochemical staining showed that the tumor cells were positive for S-100, vimentin and neuron-specific enolase and negative for α-smooth muscle actin, myoglobin and c-kit. Fluorescence in situ hybridization using a Ewing sarcoma breakpoint region 1 probe showed split signals in a small percentage of cells. We finally diagnosed the patient with clear cell sarcoma of the esophagus.

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Disclosures

Conflict of Interest:

Daisuke Ishii, Mitsuhiro Inagaki, Tatsuya Shonaka, Hiromitsu Akabane, Naoyuki Yanagida, Hiroki Shomura, Tatsuya Orimo, Takeshi Aiyama, Keisuke Sato, and Shiro Nakano declare that they have no conflict of interest.

Human/Animal Rights:

All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2008(5).

Informed Consent:

Informed consent was obtained from all patients for being included in the study.

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Authors and Affiliations

  1. Division of Surgery, Hokkaido P.W.F.A.C Asahikawa-Kosei General Hospital, 1 Jo 24 Chome 111, 1 Jodori, Asahikawa, 078-8211, Japan

    Daisuke Ishii, Mitsuhiro Inagaki, Tatsuya Shonaka, Hiromitsu Akabane, Naoyuki Yanagida, Hiroki Shomura, Tatsuya Orimo, Takeshi Aiyama & Shiro Nakano

  2. Department of Pathology, Asahikawa Medical University, 2-1 Midorigaoka-Higashi, Asahikawa, 078-8510, Japan

    Keisuke Sato

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  1. Daisuke Ishii
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  2. Mitsuhiro Inagaki
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Correspondence to Daisuke Ishii.

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Ishii, D., Inagaki, M., Shonaka, T. et al. Clear cell sarcoma of the esophagus: report of a case. Clin J Gastroenterol 7, 228–232 (2014). https://doi.org/10.1007/s12328-014-0479-1

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  • DOI: https://doi.org/10.1007/s12328-014-0479-1

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