The Cerebellum

, Volume 13, Issue 2, pp 215–221

Recessive Spinocerebellar Ataxia with Paroxysmal Cough Attacks: A Report of Five Cases

  • Luis Velázquez-Pérez
  • Rigoberto González-Piña
  • Roberto Rodríguez-Labrada
  • Raul Aguilera-Rodríguez
  • Lourdes Galicia-Polo
  • Yaimeé Vázquez-Mojena
  • Ana M. Cortés-Rubio
  • Marla R. Trujillo-Bracamontes
  • Cesar M. Cerecedo-Zapata
  • Oscar Hernández-Hernández
  • Bulmaro Cisneros
  • Jonathan J. Magaña
Original Paper

DOI: 10.1007/s12311-013-0526-3

Cite this article as:
Velázquez-Pérez, L., González-Piña, R., Rodríguez-Labrada, R. et al. Cerebellum (2014) 13: 215. doi:10.1007/s12311-013-0526-3

Abstract

Hereditary ataxias are a heterogeneous group of neurological diseases characterized by progressive cerebellar syndrome and numerous other features, which result in great diversity of ataxia subtypes. Despite the characterization of a number of both autosomal dominant and autosomal recessive ataxias, it is thought that a large group of these conditions remains to be identified. In this study, we report the characterization of five patients (three Mexicans and two Italians) who exhibit a peculiar form of recessive ataxia associated with coughing. The main clinical and neurophysiological features of these patients include cerebellar ataxia, paroxysmal cough, restless legs syndrome (RLS), choreic movements, atrophy of distal muscles, and oculomotor disorders. Brain magnetic resonance imaging (MRI) revealed cerebellar atrophy, while video polysomnography (VPSG) studies showed a severe pattern of breathing-related sleep disorder, including sleep apnea, snoring, and significant oxygen saturation in the absence of risk factors. All patients share clinical features in the peripheral nervous system, including reduction of amplitude and prolonged latency of sensory potentials in median and sural nerves. Altogether, clinical criteria as well as molecular genetic testing that was negative for different autosomal dominant and autosomal recessive ataxias suggest the presence of a new form of recessive ataxia. This ataxia, in which cerebellar signs are preceded by paroxysmal cough, affects not only the cerebellum and its fiber connections, but also the sensory peripheral nervous system and extracerebellar central pathways.

Keywords

AtaxiaAutosomal recessive ataxiaAutosomal dominant ataxiaCerebellar atrophySensory neuropathySleep disorder paroxysmal cough

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Luis Velázquez-Pérez
    • 1
  • Rigoberto González-Piña
    • 2
  • Roberto Rodríguez-Labrada
    • 1
  • Raul Aguilera-Rodríguez
    • 1
  • Lourdes Galicia-Polo
    • 3
  • Yaimeé Vázquez-Mojena
    • 1
  • Ana M. Cortés-Rubio
    • 4
  • Marla R. Trujillo-Bracamontes
    • 5
  • Cesar M. Cerecedo-Zapata
    • 6
  • Oscar Hernández-Hernández
    • 6
  • Bulmaro Cisneros
    • 7
  • Jonathan J. Magaña
    • 6
  1. 1.Center for the Research and Rehabilitation of the Hereditary Ataxias (CIRAH)HolguínCuba
  2. 2.Department of Brain PlasticityNational Rehabilitation Institute (INR)Mexico CityMexico
  3. 3.Clinic of Sleep Disorders, School of MedicineUNAMMexico CityMexico
  4. 4.Magnetic Resonance ServiceINRMexico CityMexico
  5. 5.Department of Audiology and OtoneurologyINRMexico CityMexico
  6. 6.Laboratory of Genomic Medicine, Department of GeneticsINRMexico CityMexico
  7. 7.Departament of Genetics and Molecular BiologyCINVESTAV-IPNMexico CityMexico