Journal Club

The Cerebellum

, Volume 12, Issue 6, pp 950-955

First online:

Defining the Role of Cerebellar Purkinje Cells in Autism Spectrum Disorders

  • Anamaria SudarovAffiliated withBrain and Mind Research Institute, Weill Cornell Medical College Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Understanding the contribution of cerebellar dysfunction to complex neurological diseases such as autism spectrum disorders (ASD) is an ongoing topic of investigation. In a recent paper, Tsai et al. (Nature 488:647–651, 2012) used a powerful combination of conditional mouse genetics, electrophysiology, behavioral tests, and pharmacological manipulations to address the role of Tuberous sclerosis complex 1 (Tsc1) in Purkinje cells and cerebellar function. The authors make the staggering discovery that morphological and electrophysiological defects in Purkinje cells are linked to system-wide ASD-like behavioral deficits. In this journal club, I discuss the major findings of this paper and critically assess the implications of this seminal work.


ASD Tsc1 Purkinje cells Behavior Synapses