The Cerebellum

, Volume 12, Issue 6, pp 950–955

Defining the Role of Cerebellar Purkinje Cells in Autism Spectrum Disorders

Journal Club

DOI: 10.1007/s12311-013-0490-y

Cite this article as:
Sudarov, A. Cerebellum (2013) 12: 950. doi:10.1007/s12311-013-0490-y


Understanding the contribution of cerebellar dysfunction to complex neurological diseases such as autism spectrum disorders (ASD) is an ongoing topic of investigation. In a recent paper, Tsai et al. (Nature 488:647–651, 2012) used a powerful combination of conditional mouse genetics, electrophysiology, behavioral tests, and pharmacological manipulations to address the role of Tuberous sclerosis complex 1 (Tsc1) in Purkinje cells and cerebellar function. The authors make the staggering discovery that morphological and electrophysiological defects in Purkinje cells are linked to system-wide ASD-like behavioral deficits. In this journal club, I discuss the major findings of this paper and critically assess the implications of this seminal work.


ASDTsc1Purkinje cellsBehaviorSynapses

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  1. 1.Brain and Mind Research InstituteWeill Cornell Medical CollegeNew YorkUSA