, Volume 9, Issue 4, pp 603-605
Date: 25 Aug 2010

Depressive Mood is Associated with Ataxic and Non-Ataxic Neurological Dysfunction in SCA3 Patients

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We read with interest the article recently published in Cerebellum by Klinke et al., entitled “Neuropsychological features of patients with spinocerebellar ataxia (SCA) types 1, 2, 3, and 6,” particularly because it pertains to the depressive mood scores obtained in those patients [1]. SCAs are a group of autosomal dominant ataxic disorders affecting mainly the cerebellum and its afferent and efferent connections; however, in most SCAs the consecutive degenerative process also involves extracerebellar structures [2].

A recent survey of subjective health status performed in 526 SCA patients from the European Integrated Project on Spinocerebellar Ataxias (EUROSCA) clinical group, found that 46% of those patients reported depression/anxiety problems, which was one of the three independent predictors of subjective health status together with ataxia severity and extent of noncerebellar involvement [3]. We previously reported that SCA3 symptomatic patients have higher depressive mood scores o ...