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Effect of Interaction Between Duration of Alcohol Consumption and Alcohol Dependence on Thyroid Function Test: Cross Sectional Observational Study

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Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

Dependence on alcohol, nicotine and duration of alcohol consumption are known to alter thyroid function tests. This study was conducted to assess the effect of interaction between the duration of alcohol consumption and alcohol dependence on TFT. The subjects consisted of 38 male patients with alcohol dependent syndrome co morbid with nicotine dependent syndrome, 33 male patients with alcohol dependent syndrome and 30 male normal healthy volunteers. Liver function tests, haematological parameters and thyroid function tests were assayed. Two way multivariate ANOVA was used to assess the interaction effect by SPSS 21 package. Multivariate analysis of combined TFT levels revealed no significant (P = .078) difference amongst groups based on alcohol dependence, significant difference (P = .001) amongst groups based on duration of alcohol consumption and no significant (P = .604) interaction effect between duration of alcohol consumption and alcohol dependence. Tests of between subject effects for individual TFT revealed significant (P = .014) difference in T3 between groups based on alcohol dependence, significant difference in the levels of fT4 (P = .001), T3 (P = .07) and T4 (P < .001) between groups based on duration of alcohol consumption was observed. Interaction between the effect of duration of alcohol consumption and alcohol dependence for individual TFT did not reveal any significance. fT4, TSH and T4 levels were significantly low in persons consuming alcohol for more than 20 years. TSH levels were significantly low in ADS compared to controls. Significant decrease in the levels of thyroid hormones was observed as the duration of alcohol consumption increased.

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Acknowledgements

All the authors wish to thank the authority of Father Muller Medical College for providing infrastructure and support.

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Authors and Affiliations

  1. Department of Biochemistry, Father Muller Medical College, Father Muller Road, Kankanady, Mangalore, Karnataka, India

    J. B. Honnamurthy, A. R. Shivashankara, S. S. Avinash & M. Malathi

  2. Department of Psychiatry, Father Muller Medical College, Father Muller Road, Kankanady, Mangalore, Karnataka, India

    P. John Mathai

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  1. J. B. Honnamurthy
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  2. A. R. Shivashankara
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Correspondence to J. B. Honnamurthy.

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Conflict of interest

J. B. Honnamurthy, A. R. Shivashankara, S. S. Avinash, P. John Mathai, and M. Malathi declare that they have no conflict of interest.

Ethical Standard

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study was approved by Father Muller Institutional ethics committee (FMMC/FMIEC/2039/2014).

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All authors declare that written informed consent was obtained from all individual participants included in the study.

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Honnamurthy, J.B., Shivashankara, A.R., Avinash, S.S. et al. Effect of Interaction Between Duration of Alcohol Consumption and Alcohol Dependence on Thyroid Function Test: Cross Sectional Observational Study. Ind J Clin Biochem 33, 61–68 (2018). https://doi.org/10.1007/s12291-017-0645-6

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  • DOI: https://doi.org/10.1007/s12291-017-0645-6

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