Skip to main content

Advertisement

Log in

Oxidative Stress Correlates with Complications Among Diabetic Patients Attending a Diabetic Clinic in Muhimbili National Hospital, Dar es Salaam, Tanzania

  • Original Article
  • Published:
Indian Journal of Clinical Biochemistry Aims and scope Submit manuscript

Abstract

In diabetes, persistent hyperglycemia results in increased production of free radicals especially oxygen free radicals, which can cause cell destruction and tissue injury resulting in cell dysfunction. With the premise that oxidative stress is a major cause of diabetic complications, we conducted a controlled laboratory based investigation on level of lipid peroxide levels in the serum of Type 1 and Type 2 diabetic patients attending Muhimbili National Hospital. From our clinical data it was observed that majority of the patients had higher waist to hip ration and body mass index, which suggests that the patients were either overweight or obese. The enrolled diabetic patients had higher lipid peroxide levels than controls and also Type 2 patients had higher lipid peroxide levels than Type 1 patients. Moreover, patients with known complications had higher lipid peroxide levels than patients without complications. The lipid peroxide levels in the diabetic patients were significantly different from that of the control subjects enrolled in the study. A majority of the diabetic patients had a poorly controlled blood sugar. Our finding hints that despite the fact that diabetic patients in our clinic are on follow up, they are at a risk of developing coronary heart diseases, neuropathy and other secondary diabetic complications.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Lyons TJ, Jenkins AJ. Glycation, oxidation and lipoxidation in the development of complications of diabetes: a carbonyl stress hypothesis. Diabetes Rev. 1997;5(4):365–91.

    Google Scholar 

  2. Maritim AC, Sanders RA, Watkins JB. Diabetes, oxidative stress, and antioxidants: a review. J Biochem Mol Toxicol. 2003;17(1):24–38.

    Article  PubMed  CAS  Google Scholar 

  3. Cerielo A. Oxidative stress and diabetes associated complications. Endocr Pract. 2006;12(Suppl 1):60–2.

    Google Scholar 

  4. Ha H, Lee HB. Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose. Kidney Int Suppl. 2000;77:S19–25.

    Article  PubMed  CAS  Google Scholar 

  5. Brownlee M. Biochemistry and molecular cell biology of diabetic complication. Nature. 2001;414:813–20.

    Article  PubMed  CAS  Google Scholar 

  6. Lions TJ. Oxidized low density lipoproteins: a role in the pathogenesis of atherosclerosis in diabetes. Diabet Med. 1991;8:411–9.

    Article  Google Scholar 

  7. Martin-Gallan P, Carrascosa A, Gussinye M, Dominguez C. Biomarkers of diabetes-associated oxidative stress and antioxidant status in young diabetic patients with or without subclinical complications. Free Radic Biol Med. 2003;34:1563–74.

    Article  PubMed  CAS  Google Scholar 

  8. Baynes JW, Thorpe SR. Role of oxidative stress in diabetic complications: a new perspective on an old paradigm. Diabetes. 1999;48:1–9.

    Article  PubMed  CAS  Google Scholar 

  9. Jeanette SJ, Alex KH, David JR, Adviye E. Oxidative stress and the use of antioxidants in diabetes: linking basic science to clinical practice. Cardiovasc Diabetol. 2005;4:5. doi:10.1186/1475-2840-4-5.

    Article  Google Scholar 

  10. Hink U, Li H, Mollnau H, Oelze M, Matheis E, Hartmann M, Skatchkov M, Thaiss F, Stahl RA, Warnholtz A, Meinertz T, Griendling K, Harrison DG, Forstermann U, Munzel T. Mechanisms underlying endothelial dysfunction in diabetes mellitus. Circ Res. 2001;88:E14–22.

    Article  PubMed  CAS  Google Scholar 

  11. Baynes JW. Role of oxidative stress in development of complications in diabetes. Diabetes. 1991;40:405–12.

    Article  PubMed  CAS  Google Scholar 

  12. Oberley LW. Free radicals and diabetes. J Free Radic Biol Med. 1988;5:113–24.

    Article  CAS  Google Scholar 

  13. Parinandi NL, Thomson EW, Schmid HO. Diabetic heart and kidney exhibit increased resistance to lipid peroxidation. Biochem Biophys Acta. 1990;1047:63–9.

    Article  PubMed  CAS  Google Scholar 

  14. Schmidt AM, Stern D. Atherosclerosis and diabetes: the RAGE connection. Curr Atheroscler Rep. 2000;2:430–6.

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgments

We thank the MNH administration for allowing us enroll diabetic patients and for use of the available space. We thank the MUHAS-Harvard Research Laboratory for allowing us to use their Roche diagnostics Cobas Integra 400 plus analyzer.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Solomon Genet.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Genet, S., Lema, Y. & Lutale, J. Oxidative Stress Correlates with Complications Among Diabetic Patients Attending a Diabetic Clinic in Muhimbili National Hospital, Dar es Salaam, Tanzania. Ind J Clin Biochem 28, 177–180 (2013). https://doi.org/10.1007/s12291-012-0276-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12291-012-0276-x

Keywords

Navigation