Skip to main content

Advertisement

SpringerLink
Log in

A Study of Platelet Indices in Type 2 Diabetes Mellitus Patients

  • Original Article
  • Published:
Indian Journal of Hematology and Blood Transfusion Aims and scope Submit manuscript

Abstract

Altered platelets have been reported in patients with diabetes mellitus and has been considered as a ‘prothrombotic state’ with enhanced platelet reactivity. They have been associated with increased risk of vascular complications in these patients. Platelet indices correlate with functional status of platelets and is an emerging risk factor of vascular complications in diabetes. The study was undertaken to know the efficacy of platelet analysis in assessing the prognosis of diabetes mellitus. A prospective hospital based study of platelet parameters MPV, PDW and P-LCR was carried out on 280 cases diagnosed with Type 2 diabetes Mellitus and 280 controls with normal blood glucose levels. The blood glucose levels and HbA1c level were also measured. Statistical evaluation was performed by using Student’s unpaired t test and Pearson correlation test. The average age of presentation with type 2 diabetes mellitus was 53 ± 5.7 years. The mean duration of diabetes was 4.7 ± 2.5 years. MPV, PDW and P-LCR were significantly higher in diabetics compared to non diabetics (11.3 ± 1.0 vs. 9.0 ± 0.6, 14.2 ± 2.5 vs. 10.7 ± 0.7 fl, 35.0 ± 8.1 vs. 23.0 ± 2.4%). Among the diabetics, MPV, PDW and P-LCR were higher in those with complications as compared to those without complications, which was not statistically significant. The higher values of MPV, PDW and P-LCR indicates that they serve as better risk indicator of initial vascular complications in diabetes mellitus patients and can be used as a simple and cost effective tool to assess vascular events.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Alberti KGMM, Zimmet PZ, World Health Organization (2015) Definition, diagnosis and classification of diabetes mellitus and its complications: report of a WHO consultation. Part 1. Diagnosis and classification of diabetes mellitus. Geneva. Diabet Med 15:539–553

    Article  Google Scholar 

  2. Keating FK, Sobel BE, Schneider DJ (2003) Effects of increased concentrations of glucose on platelet reactivity in healthy subjects and in patients with and without diabetes. Am J Cardiol 92:1362–1365

    Article  CAS  PubMed  Google Scholar 

  3. Mishra J, Shah P, Sanil R (2012) Hematological disorders from The Kota Tribes of the Nilgris, India. Asian J Biochem Pharm Res 2:156–162

    Google Scholar 

  4. Yesudian C, Grepstad M, Visintin E, Ferrario A (2014) The economic burden of diabetes in India: a review of the literature. Glob Health 10:1–18

    Article  Google Scholar 

  5. Genuth S, Alberti KG, Bennett P, Buse J, Defronzo R, Kahn R et al (2003) Expert committee on the diagnosis and classification of diabetes mellitus2. Follow-up report on the diagnosis of diabetes mellitus. Diabetes Care 26:3160–3167

    Article  PubMed  Google Scholar 

  6. Hekimsoy Z, Payzin B, Ornek T, Kandoğan G (2004) Mean platelet volume in type 2 diabetic patients. J Diabet Complicat 18:173–176

    Article  Google Scholar 

  7. Gaikwad A, Kanitkar S, Kalyan M, Tamakuwala K, Agarwal R, Bhimavarapu B (2014) Prevalence of type 2 diabetes mellitus in candidates contesting for municipal corporation elections in an urban industrialized town. Indian J Basic Appl Med Res 3:412–418

    Google Scholar 

  8. Hers I (2007) Insulin-like growth factor-1 potentiates platelet activation via the IRS/PI3Kalpha pathway. Blood 110:4243–4252

    Article  CAS  PubMed  Google Scholar 

  9. Stratmann B, Tschoepe D (2005) Pathobiology and cell inter-actions of platelets in diabetes. Diab Vasc Dis Res 2:16–23

    Article  PubMed  Google Scholar 

  10. Mowafy N, Metwaly E, Hashish B, Bazeed M (2015) A study of the value of some platelet parameters in patients with type 2 diabetes mellitus. Al-Azhar Assiut Med J 13:13–18

    Google Scholar 

  11. Kodiatte TA, Manikyam UK, Rao SB, Jagadish TM, Reddy M, Lingaiah HK (2012) Mean platelet volume in type 2 diabetes mellitus. J Lab Phys 14:5–9

    Google Scholar 

  12. Italiano JE, Gresele P, Fuster V, Lopez JA (2008) The structure and production of blood platelets. In: Gresele P, Fuster V, Lopez JA, Page CP (eds) Platelets in hematologic and cardiovascular disorders, 1st edn. Cambridge University Press, New York, pp 1–20

    Google Scholar 

  13. Chang HA, Hwang HS, Park HK, Chun MY, Sung JY (2010) The role of mean platelet volume as a predicting factor of asymptomatic coronary artery disease. Korean J Fam Med 31:600–606

    Article  Google Scholar 

  14. Vinik AI, Erbas T, Park TS, Nolan R, Pittenger GL (2001) Platelet dysfunction in type 2 diabetes. Diabetes Care 24:1476–1485

    Article  CAS  PubMed  Google Scholar 

  15. Jindal S, Gupta S, Gupta R, Kakkar A, Singh HV, Gupta K, Singh S (2011) Platelet indices in diabetes mellitus: indicators of diabetic microvascular complications. Hematology 16:86–90

    Article  PubMed  Google Scholar 

  16. Zuberi BF, Akhtar N, Afsar S (2008) Comparison of mean platelet volume in patients with diabetes mellitus, impaired fasting glucose and non-diabetic subjects. Singap Med J 49:114–116

    CAS  Google Scholar 

  17. Demirtunc R, Duman D, Basar M, Bilgi M, Teomete M, Garip T (2009) The relationship between glycemic control and platelet activity in type 2 diabetes mellitus. J Diabet Complicat 23:89–94

    Article  Google Scholar 

  18. Akinsegun A, Olusola D, Sarah J, Olajumoke O, Adewumi A, Majeed O et al (2014) Mean platelet volume and platelet counts in type 2 Diabetes: mellitus on treatment and non-diabetic mellitus controls in Lagos, Nigeria. Pan Afr Med J 18:1–5

    Article  Google Scholar 

  19. Ozder A, Eker H (2014) Investigation of mean platelet volume in patients with type 2 diabetes mellitus and in subjects with impaired fasting glucose: a cost-effective tool in primary health care. Int J Clin Exp Med 7:2292–2297

    PubMed  PubMed Central  Google Scholar 

  20. Ulutas K, Dokuyucu R, Sefil F, Yengil E, Sumbul A, Rizaoglu H et al (2014) Evaluation of mean platelet volume in patients with type 2 diabetes mellitus and blood glucose regulation: a marker for atherosclerosis. Int J Clin Exp Med 7:955–961

    PubMed  PubMed Central  Google Scholar 

  21. Papanas N, Symeonidis G, Maltezos E, Mavridis G, Karavageli E, Vosnakidis T et al (2004) Mean platelet volume in patients with type 2 diabetes mellitus. Platelets 15:475–478

    Article  CAS  PubMed  Google Scholar 

  22. Demirtas L, Degirmenci H, Akbas E, Ozcicek A, Timuroglu A, Gure A et al (2015) Association of hematological indicies with diabetes, impaired glucose regulation and microvascular complications of diabetes. Int J Clin Exp Med 8:11420–11427

    PubMed  PubMed Central  Google Scholar 

  23. Jabeen F, Rizvi H, Aziz F, Wasti A (2013) Hyperglycemic induced variations in hematological indices in type 2 diabetics. Int J Adv Res 1:322–334

    Google Scholar 

  24. Dalamaga M, Karmaniolas K, Lekkab A, Antonakosa G, Thrasyvoulides A, Papadavid E et al (2010) Platelet markers correlate with glycemic indices in diabetic, but not diabetic myelodysplastic patients with normal platelet count. Dis Markers 29:55–61

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  25. Ashraf S, Ranjan R, Singh S, Singh H, Kudesia M, Sharma R (2017) Diabetes disease burden by platelet indices as possible biomarkers in evaluation of initial vascular risks in grading diabetes mellitus: correlation of platelet dysfunction indices with hematopoietic and biochemical biomarkers in diabetes mellitus. Open J Biochem 1–15 (in press)

Download references

Acknowledgements

Granted by the institution B.L.D.E.U’S Shri.B.M.Patil Medical College, Hospital and Research Centre, Vijayapura.

Author information

Authors and Affiliations

  1. Department of Pathology, Shri. B.M. Patil Medical College, Hospital and Research Centre, Solapur road, Vijayapura, Karnataka, 586103, India

    Kumari Shilpi & R. M. Potekar

Authors
  1. Kumari Shilpi
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. M. Potekar
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Kumari Shilpi.

Ethics declarations

Conflict of interest

Author Dr. Kumari Shilpi declares that she has no conflict of interest. Author Dr. R. M. Potekar declares that he has no conflict of interest.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed Consent

Informed consent was obtained from all individual participants included in the study.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Shilpi, K., Potekar, R.M. A Study of Platelet Indices in Type 2 Diabetes Mellitus Patients. Indian J Hematol Blood Transfus 34, 115–120 (2018). https://doi.org/10.1007/s12288-017-0825-9

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12288-017-0825-9

Keywords

Search

Navigation