Abstract
Acute lymphoblastic leukemia (ALL) is a haematological malignancy that can involve the central nervous system (CNS). Less than 10 % of patients with ALL have CNS involvement at presentation. The cranial nerve most commonly affected is cranial nerve VII although bilateral involvement is rare. Management and outcomes of these patients are not well understood. Moreover bilateral Bells palsy as a presenting symptom of ALL is extremely uncommon. We report a very unusual presentation of ALL with bilateral facial nerve palsy, and discuss the management strategies and outcomes for patients with ALL that present with cranial nerve palsies.
References
Kantarjian H, O’Brien S, Smith T et al (2000) Results of treatment with hyper-CVAD, a dose intensive regimen, in adult acute lymphocytic leukemia. J Clin Oncol 1(18):547–561
Rowe J, Buck G, Burnett A et al (2005) Induction therapy for adults with acute lymphoblastic leukemia: results of more than 1500 patients from the international ALL trial: MRC UKALL XII/ECOG E2993. Blood 106(12):3760–3767
Lazarus HM, Richards SM, Chopra R et al (2006) Central nervous system involvement in adult acute lymphoblastic leukemia at diagnosis: results from the international ALL trial MRC UKALL XII/ECOG E2993. Blood 108(2):465–472
Peitersen E (2002) Bell’s palsy: the spontaneous course of 2,500 peripheral facial nerve palsies of different etiologies. Acta Otolaryngol 549:4–30
Michaelis E, Rupprecht L, Mortier W (1974) Primary neurologic symptoms in diffuse lymphoreticular neoplasias. Monatsschr Kinderheilkd. 122(7):433–434
Garvey P, Lawrence J (1933) Facial diplegia in lymphatic leukaemia. JAMA 101(25):194
Van Rossum J, Zwaan F, Bots G (1979) Facial palsy as the initial symptom of a lymphoreticular malignancy. Eur Neurol 18(3):212–216
Kurabayashi H, Miyawaki S, Naruse T et al (1989) Bilateral tympanic cavity infiltration with effusion in a patient with acute myeloblastic leukemia. Blut 58(1):45–46
Almadori G, Del Ninno M, Cadoni G et al (1996) Facial nerve paralysis in acute otomastoiditis as presenting symptom of FAB M2, T8;21 leukemic relapse. Case report and review of the literature. Int J Pediatr Otorhinolaryngol 36(1):45–52
Grose C, Herle W, Henle G et al (1975) Primary Epstein–Barr-virus infections in acute neurologic diseases. N Engl J Med 292(8):392–395
Gallo R (1982) Regulation of human T-ceil proliferation: T-cell growth factor T-ceil leukaemia and lymphomas and isolation of a new c-type retrovirus. In: Rosenberg, Kapler (eds) Malignant lymphomas. Academic Press, New York, p 201
Mulvihill J, Eckman W, Fraumeni J et al (1973) Arch Intern Med 132(1):116–117
Leibel S, Philips T (1998) Textbook of radiation oncology. WB Saunders, Philadelphia
Gray JR, Wallner KE (1990) Reversal of cranial nerve dysfunction with radiation therapy in adults with lymphoma and leukemia. Int J Radiat Oncol Biol Phys 19:439–444
Ha CS, Chung WK, Koller CA et al (1999) Role of radiation therapy to the brain in leukemic patients with cranial nerve palsies in the absence of radiological findings. Leuk Lymphoma 32:497–503
Ingram LC, Fairclough DL, Furman WL et al (1991) Cranial nerve palsy in childhood acute lymphoblastic leukemia and non-Hodgkin’s lymphoma. Cancer 67:2262–2268
Buykavci M et al (2002) An alarming sign for serious disease in children: bilateral facial paralysis. Pediatr Neurol 27:312–313
Ozcakar L, Akinci A, Özgöçmen S et al (2003) Bell’s palsy as an early manifestation of acute lymphoblastic leukemia. Ann Hematol 82:124–126
Smith V, Traquina D (1998) Pediatric bilateral facial paralysis. Laryngoscope 108(3):519–523
Averbach-Heller L, Gills S, Ben-Hur T (1994) Transient sixth-nerve palsy as the first presentation of acute leukemia. J Neurol Neurosurg Psychiatry 57:506
de Fatima Soares M, Braga FT, da Rocha AJ et al (2005) Optic nerve infiltration by acute lymphoblastic leukemia: MRI contribution. Pediatr Radiol 37:799–802
Hsu WH, Chu SJ, Tsai WC et al (2008) Acute myeloid leukemia presenting as one-and-a-half syndrome. Am J Emerg Med 26:513.e1–513.e2
Kulkarni KP, Marwaha RK, Trehan A et al (2009) Isolated right anterior chamber relapse in a patient of acute lymphoblastic leukemia presenting with facial nerve palsy. J Pediatr Hematol Oncol 31:990–991
Tageja N, Valent J, Bentley G et al (2010) Precursor T cell acute lymphoblastic lymphoma presenting as bilateral facial nerve palsy. Chemotherapy 56:258–260
Sasaki M, Yamazaki H, Aoki T et al (2011) Bilateral numb chin syndrome leading to a diagnosis of Burkitt’s cell acute lymphocytic leukemia: a case report and literature review. Oral Surg Med Oral Pathol Oral Radiol Endod 111:e11–e16
Young J, Susumu I (1996) Facial nerve palsy as an early manifestation of relapse in T-cell acute lymphoblastic leukemia. Ear Nose Throat J 75:157
Ferrari J, Lang W, Thurnher S et al (2004) Bilateral facial nerve palsy as first indication of relapsing hairy cell leukemia after 36 years. Neurology 63:399–400
Zappia J, Bunge F, Koopmann C et al (1990) Facial nerve paresis as the presenting symptom of leukemia. Int J Pediatr Otorhinolaryngol 19:259–264
Sood B, Sharma B, Sharma A et al (2003) Facial palsy as first presentation of acute myeloid leukemia. Am J Hematol 74:200–201
Bilavsky, Scheuerman O, Garty B et al (2006) Facial paralysis as a presenting symptom of leukemia. Pediatr Neurol 34:502–504
Karadag D, Karagulle A, Erden A et al (2002) Trigeminal nerve involvement in T-cell acute lymphoblastic leukemia: value of MR imaging. Eur J Radiol 44:16–18
Marwaha R, Kulkarni K, Trehan A et al (2010) Central nervous system involvement at presentation in childhood acute lymphoblastic leukemia: management experience and lessons. Leuk Lymphoma 51:261–268
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Sen, S., Gupta, A., Friedman, P. et al. Bilateral Facial Nerve Palsy in Acute B Cell Lymphoblastic Leukemia: A Case Report and Review of the Literature. Indian J Hematol Blood Transfus 32 (Suppl 1), 15–19 (2016). https://doi.org/10.1007/s12288-015-0526-1
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DOI: https://doi.org/10.1007/s12288-015-0526-1