Abstract
Megaloblastic anemia (MA) is a common disorder with varied manifestations. It generally results in mild to moderate splenomegaly which is due to sequestration of macrocytic erythrocytes in spleen. Massive splenomegaly is generally seen in infections, myeloproliferative diseases, neoplasms, storage disorders or hematological conditions; but is not heard of and has rarely been reported in MA. We discuss a case of massive splenomegaly who presented with symptomatic anemia and was found to have MA. He was extensive evaluated for all other causes of massive splenomegaly which was normal. Further, after a therapeutic trial of MA he showed a regression in spleen size confirming that the massive splenomegaly was attributable to MA.
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References
Greer JP, Forester J, Rodgers GM, Paraskevas F et al (eds) (2009) Wintrobe’s clinical hematology, 12th edn. Lippincott Williams & Wilkins, Philadelphia, pp 1143–1172
Longo D, Fauci A, Kasper D (2012) Harrisons principles of internal medicine, 18th edn. The McGraw-Hill Companies Inc, New York, pp 862–871
MacCarty WC (1928) Chronic splenomegaly. Arch Intern Med 41:536–548
Pruthi RK (1993) Reversible marked splenomegaly in pernicious anemia. Ann Intern Med 119:1053
Enokihara H, Saito K, Hazama S, Hirose K, Komatsu H, Furusawa S et al (1978) A case of pernicious anemia with giant splenomegaly. Jap J clin hematol 19(12):1684–1689
O’Reilly RA (1998) Splenomegaly in 2,505 patients at a large university medical centre. West J Med 169:78–87
Bigg E (1940) Spleen size in pernicious anemia. Ann Intern Med 14:277–280
Limal N, Scheuermaier K, Tazi Z, Sene D, Piette JC, Cacoub P (2006) Hyperhomocysteinaemia, thrombosis and pernicious anaemia. Thromb Haemost 96(2):233–235
Fernández-Ruiz M, Alonso-Navas F, Muro E, Pérez-Carreras M (2011) Portal and mesenteric vein thrombosis associated with hyperhomocysteinemia and pernicious anemia in a patient heterozygous for the MTHFR C677T mutation. Med Clin (Barc) 136(5):225–226
Erkurt MA, Aydogdu I, Dikilitaş M, Kuku I, Kaya E, Bayraktar N et al (2008) Effects of cyanocobalamin on immunity in patients with pernicious anemia. Med Princ Pract 17(2):131–135
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Behera, V., Randive, M., Sharma, P. et al. Megaloblastic Anemia Presenting with Massive Reversible Splenomegaly. Indian J Hematol Blood Transfus 31, 297–299 (2015). https://doi.org/10.1007/s12288-014-0461-6
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DOI: https://doi.org/10.1007/s12288-014-0461-6