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Juvenile Myelomonocytic Leukemia in India: Cure Remains a Distant Dream!

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Abstract

There is paucity of outcome data regarding juvenile myelomonocytic leukemia from India. We report a series of eight children. Three had monosomy 7 and one had complex cytogenetics. One with Down’s syndrome recovered spontaneously. Three refused therapy of whom only one is alive with disease. One died post chemotherapy. Three underwent allogeneic stem cell transplant after protracted delay with funds arranged from various governmental and non-governmental organizations. Of these two died (relapse-1 and intracranial bleed-1) and one is alive and disease free. In India, it’s a milestone to reach transplant due to high cost and cure still remains a distant dream.

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References

  1. Niemeyer CM, Arico M, Basso G, Biondi A, Cantu Rajnoldi A, Creutzig U et al (1997) Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. Blood 89:3534–3543

    PubMed  CAS  Google Scholar 

  2. Emanual PD (1999) Myelodysplasia and myeloproliferative disorders in childhood: an update. Br J Haematol 105:852–863

    Article  Google Scholar 

  3. Arico M, Biondi A, Pui CH (1997) Juvenile myelomonocytic leukaemia. Blood 90:479–488

    PubMed  CAS  Google Scholar 

  4. Chan RJ, Cooper T, Kratz CP et al (2009) Juvenile myelomonocytic leukemia: a report from the 2nd international JMML symposium. Leuk Res 33(3):355–362

    Article  PubMed  PubMed Central  Google Scholar 

  5. Locatelli F, Nollke P, Zecca M et al (2005) Hematopoietic stem cell transplantation (HSCT) in children with juvenile myelomonocytic leukemia (JMML): results of the EWOG-MDS/EBMT trial. Blood 105:410–419

    Article  PubMed  CAS  Google Scholar 

  6. Manabe A, Okamura J, Yumura-Yagi K et al (2002) Allogeneic hematopoietic stem cell transplantation for 27 children with juvenile myelomonocytic leukemia diagnosed based on the criteria of the international JMML Working Group. Leukemia 16:645–649

    Article  PubMed  CAS  Google Scholar 

  7. Crombet O, Svarch E (1999) Down syndrome and Juvenile myelomonocytic leukemia. Pediatr Hematol Oncol 16(2):181–182

    Article  PubMed  CAS  Google Scholar 

  8. Arya LS, Bhatia P, Jain Y, Choudhry VP, Verma IC, Chinnappan D, Pati HP (1995) Juvenile chronic myelocytic leukemia-report of ten cases. Med Pediatr Oncol 24:100–103

    Article  PubMed  CAS  Google Scholar 

  9. Puri K, Singh S, Das RR, Seth R, Gupta R (2011) Diagnostic dilemma of JMML coexisting with CMV infection. Indian J Pediatr 78(4):485–487

    Article  PubMed  Google Scholar 

  10. Gupta N, Gupta R, Sharawat SK, Bakhshi S (2010) Childhood chronic myeloid leukemia with monocytosis. Indian J Pediatr 77:1143–1145

    Article  PubMed  Google Scholar 

  11. Locatelli F, Madureira A, Rocha V et al (2007) Unrelated cord blood transplantation for children with juvenile myelomonocytic leukemia [abstract no. 2021]. Blood 110(11):602a72

    Google Scholar 

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Correspondence to Satya Prakash Yadav.

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Ramzan, M., Yadav, S.P., Dhingra, N. et al. Juvenile Myelomonocytic Leukemia in India: Cure Remains a Distant Dream!. Indian J Hematol Blood Transfus 30 (Suppl 1), 398–401 (2014). https://doi.org/10.1007/s12288-014-0434-9

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  • DOI: https://doi.org/10.1007/s12288-014-0434-9

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