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Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery: the impact of radiotherapy on second IBTR

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Abstract

Objectives

There are limited data on the outcomes of patients treated with repeat lumpectomy at the time of ipsilateral breast tumor recurrence (IBTR). Especially, the impact of radiotherapy (RT) on a second IBTR is unknown.

Methods

We retrospectively analyzed 143 patients from 8 institutions in Japan who underwent repeat lumpectomy after IBTR. The risk factors of a second IBTR were assessed.

Results

The median follow-up period was 4.8 years. The 5-year second IBTR-free survival rate was 80.7 %. There was a significant difference in the second IBTR-free survival rate according to RT (p = 0.0003, log-rank test). The 5-year second IBTR-free survival rates for patients who received RT after initial surgery, RT after salvage surgery, and no RT were 78.0, 93.5, and 52.7 %, respectively. Multivariate analysis revealed that RT was a significantly independent predictive factor of second IBTR-free survival.

Conclusion

Repeat lumpectomy plus RT is a reasonable option in patients who did not undergo RT at the initial surgery. In contrast, caution is needed when RT is omitted in patients who have undergone repeat lumpectomy.

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Acknowledgments

We thank Dr. Takuji Iwase and Dr. Takehiro Tanaka for critical reading of the manuscript. This study was supported in part by Grants-in-Aid for Scientific Research from the Japanese Breast Cancer Society. Dr. Tetsuya Taguchi received a research grant from Takeda and Chugai. Other authors declare that they have no conflict of interest.

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Correspondence to Makoto Ishitobi.

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Ishitobi, M., Okumura, Y., Nishimura, R. et al. Repeat lumpectomy for ipsilateral breast tumor recurrence (IBTR) after breast-conserving surgery: the impact of radiotherapy on second IBTR. Breast Cancer 21, 754–760 (2014). https://doi.org/10.1007/s12282-013-0454-6

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  • DOI: https://doi.org/10.1007/s12282-013-0454-6

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