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Fungi in Cystic Fibrosis: Recent Findings and Unresolved Questions

  • Pediatric Fungal Infections (T Lehrnbecher, Section Editor)
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Abstract

Patients with cystic fibrosis (CF) suffer from chronic airway infection and inflammation. Traditionally, bacteria have been regarded the main CF pathogens while fungi have emerged and more recently warranted greater attention. Fungi are increasingly found to colonize CF airways; however, their precise clinical impact continues to spark controversy. While the clinical relevance of allergic bronchopulmonary aspergillosis (ABPA) in CF has been established, the roles of non-ABPA Aspergillus fumigatus, Candida albicans, and other more rare emerging fungi remain poorly understood. Here, we summarize and discuss recent findings in this field and refer toward unresolved questions.

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Compliance With Ethics Guidelines

Conflict of Interest

O Eickmeier, A Hector, A Singh, SH Chotirmal, and D Hartl all declare no conflict of interest.

Human and Animal Rights and Informed Consent

This article does not contain any studies with human or animal subjects performed by any of the authors.

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Authors and Affiliations

  1. Department of Pediatric Pulmonology, Allergy and Cystic Fibrosis, Children’s Hospital, Christiane Herzog CF-Center, Goethe-University, Frankfurt a.M., Germany

    Olaf Eickmeier

  2. CF Research Group, Children’s Hospital, Department I, University of Tuebingen, Tuebingen, Germany

    Andreas Hector, Anurag Singh & Dominik Hartl

  3. Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore

    Sanjay H. Chotirmall

  4. Children’s Hospital and Interdisciplinary Center for Infectious Diseases, University of Tübingen, Hoppe-Seyler-Str. 1, 72076, Tübingen, Germany

    Dominik Hartl

Authors
  1. Olaf Eickmeier
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  2. Andreas Hector
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  3. Anurag Singh
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  4. Sanjay H. Chotirmall
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  5. Dominik Hartl
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Corresponding author

Correspondence to Dominik Hartl.

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This article is part of the Topical Collection on Pediatric Fungal Infections

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Eickmeier, O., Hector, A., Singh, A. et al. Fungi in Cystic Fibrosis: Recent Findings and Unresolved Questions. Curr Fungal Infect Rep 9, 1–5 (2015). https://doi.org/10.1007/s12281-014-0211-0

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  • DOI: https://doi.org/10.1007/s12281-014-0211-0

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