Date: 24 Jun 2012
Recent Taxonomic Developments with Candida and Other Opportunistic Yeasts
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Increases in susceptible patient populations and advances in identification methods have resulted in the continued recognition of novel yeasts as agents of human infection. Most of these agents are members of the well-recognized genera Candida, Cryptococcus, Trichosporon, and Rhodotorula. Some of these agents are “cryptic species,” members of species complexes, and may not be detectable using classical carbohydrate assimilation-based methods of yeast identification. Such species require DNA- or MALDI-based methods for correct identification, although sporadic isolates may not routinely require delineation to the individual species level. The coming end of the fungal taxonomy rules requiring separate names for sexual and asexual forms of the same fungus will hopefully allow greater clarity, as names for medically important yeast can now be based on the needs of the medical mycology community and the common goal of better communication between laboratory and clinician.
Papers of particular interest, published recently, have been highlighted as: • Of importance •• Of major importance
• Clinical and Laboratory Standards Institute. MM18-A: Interpretive criteria for identification of bacteria and fungi by DNA target sequencing; Approved Guideline. Wayne: CLSI; 2007. Lists the DNA targets currently used to identify most common fungal species.
••Hawksworth DL. Managing and coping with names of pleomorphic fungi in a period of transition. Mycosphere. 2012;3:52–64. Explains the rationale behind the end of the “one fungus-two names” taxonomic rule.CrossRef
•• Kurtzman CP, Fell JW, Boekhout T, editors. The yeasts: a taxonomic study. 5th ed. London: Elsevier; 2011. The standard manual for yeast taxonomy and identification.
Paredes K, et al. Molecular identification and antifungal susceptibility of clinical isolates of Candida rugosa species complex and proposal of the new species Candida neorugosa. J Clin Microbiol. 2012. doi:10.1128/JCM.00688-12.
Al-Sweih N, et al. Kodamaea ohmeri as an emerging pathogen: a case report and review of the literature. Med Mycol. 2011;49:766–70.PubMed
Kwon-Chung KJ, Polacheck I, Bennett JE. Improved diagnostic medium for separation of Cryptococcus neoformans var. neoformans (serotypes A and D) and Cryptococcus neoformans var. gattii (serotypes B and C). J Clin Microbiol. 1982;15:535–7.PubMed
• McTaggart L, et al. Rapid identification of Cryptococcus neoformans var. grubii, C. neoformans var. neoformans, and C. gattii by use of rapid biochemical tests, differential media, and DNA sequencing. J Clin Microbiol. 2011;49:2522–7. A very helpful description of the most recent ways to separate these two species.PubMedCrossRef
Lockhart SR, et al. Epidemiologic cutoff values for triazole drugs in Cryptococcus gattii: correlation of molecular type and in vitro susceptibility. Diagn Microbiol Infect Dis. 2012. doi:10.1016/j.diagmicrobio.2012.02.018.
- Recent Taxonomic Developments with Candida and Other Opportunistic Yeasts
Current Fungal Infection Reports
Volume 6, Issue 3 , pp 170-177
- Cover Date
- Print ISSN
- Online ISSN
- Current Science Inc.
- Additional Links
- Non-albicans Candida
- Candida species
- Cryptococcus species
- Trichosporon species
- Emerging fungal infections
- Antifungal resistance
- Yeast infection
- Industry Sectors