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Protective role of gut commensal microbes against intestinal infections

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An Erratum to this article was published on 04 January 2015

Abstract

The human gastrointestinal tract is colonized by multitudes of microorganisms that exert beneficial effects on human health. Mounting evidence suggests that intestinal microbiota contributes to host resistance against enteropathogenic bacterial infection. However, molecular details that account for such an important role has just begun to be understood. The commensal microbes in the intestine regulate gut homeostasis through activating the development of host innate immunity and producing molecules with antimicrobial activities that directly inhibit propagation of pathogenic bacteria. Understanding the protective roles of gut microbiota will provide a better insight into the molecular basis that underlies complicated interaction among host-pathogen-symbiont. In this review, we highlighted recent findings that help us broaden our knowledge of the intestinal ecosystem and thereby come up with a better strategy for combating enteropathogenic infection.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, Yonsei University College of Medicine, Seoul, 120-752, Republic of Korea

    My Young Yoon, Keehoon Lee & Sang Sun Yoon

  2. Brain Korea 21 Project for Medical Sciences, Yonsei University College of Medicine, Seoul, 120-752, Republic of Korea

    Keehoon Lee & Sang Sun Yoon

  3. Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, 120-752, Republic of Korea

    My Young Yoon & Sang Sun Yoon

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  1. My Young Yoon
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Correspondence to Sang Sun Yoon.

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Yoon, M.Y., Lee, K. & Yoon, S.S. Protective role of gut commensal microbes against intestinal infections. J Microbiol. 52, 983–989 (2014). https://doi.org/10.1007/s12275-014-4655-2

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