Nano Research

, Volume 4, Issue 12, pp 1248–1260

Multifunctional FeCo-graphitic carbon nanocrystals for combined imaging, drug delivery and tumor-specific photothermal therapy in mice

Research Article

DOI: 10.1007/s12274-011-0176-z

Cite this article as:
Sherlock, S.P. & Dai, H. Nano Res. (2011) 4: 1248. doi:10.1007/s12274-011-0176-z

Abstract

Ultrasmall FeCo-graphitic carbon shell nanocrystals (FeCo/GC) are promising multifunctional materials capable of highly efficient drug delivery in vitro and magnetic resonance imaging in vivo. In this work, we demonstrate the use of FeCo/GC for highly effective cancer therapy through combined drug delivery, tumor-selective near-infrared photothermal therapy, and cancer imaging of a 4T1 syngeneic breast cancer model. The graphitic carbon shell of the ∼4 nm FeCo/GC readily loads doxorubicin (DOX) via π-π stacking and absorbs near-infrared light giving photothermal heating. When used for cancer treatment, intravenously administrated FeCo/GC-DOX led to complete tumor regression in 45% of mice when combined with 20 min of near-infrared laser irradiation selectively heating the tumor to 43–45 °C. In addition, the use of FeCo/GC-DOX results in reduced systemic toxicity compared with free DOX and appears to be safe in mice monitored for over 1 yr. FeCo/GC-DOX is shown to be a highly integrated nanoparticle system for synergistic cancer therapy leading to tumor regression of a highly aggressive tumor model. https://static-content.springer.com/image/art%3A10.1007%2Fs12274-011-0176-z/MediaObjects/12274_2011_176_Fig1_HTML.gif

Keywords

Nanocrystalsphotothermal therapydoxorubicinhyperthermiamagnetic resonance imaging

Supplementary material

12274_2011_176_MOESM1_ESM.pdf (370 kb)
Supplementary material, approximately 370 KB.

Copyright information

© Tsinghua University Press and Springer-Verlag Berlin Heidelberg 2011

Authors and Affiliations

  1. 1.Department of ChemistryStanford UniversityStanfordUSA