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Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells

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Abstract

A new oplopane-type sesquiterpenoid tussilagofarin (1) and a new chromone tussilagofarol (2), along with 18 known compounds 3–20, were isolated from the flower buds of Tussilago farfara. The structures of the new compounds were elucidated on the basis of 1D and 2D NMR and HRESIMS data. Of the isolated compounds, oplopane- and bisabolane-type sesquterpenoids 1, 8–12, 15, and 16 were found to inhibit nitric oxide production in LPS-induced RAW 264.7 cells with IC50 values of 3.5–28.5 μM.

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Acknowledgments

This research was supported financially by the Medical Research Center Program (MRC, 2008-0062275) through the National Research Foundation of Korea.

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Authors and Affiliations

  1. College of Pharmacy, Chungbuk National University, Cheongju, 28644, Korea

    Hari Jang, Jin Woo Lee, Chul Lee, Qinghao Jin, Jeong Yeon Choi, Sang Bae Han, Youngsoo Kim, Jin Tae Hong, Mi Kyeong Lee & Bang Yeon Hwang

  2. Department of Biosystems and Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, 02841, Korea

    Dongho Lee

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  1. Hari Jang
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  2. Jin Woo Lee
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  3. Chul Lee
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  4. Qinghao Jin
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Correspondence to Bang Yeon Hwang.

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Jang, H., Lee, J.W., Lee, C. et al. Sesquiterpenoids from Tussilago farfara inhibit LPS-induced nitric oxide production in macrophage RAW 264.7 cells. Arch. Pharm. Res. 39, 127–132 (2016). https://doi.org/10.1007/s12272-015-0667-7

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  • DOI: https://doi.org/10.1007/s12272-015-0667-7

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