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Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava

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Abstract

The sap from the succulent Desmidorchis flava (N.E.Br) Meve and Liede yielded a new pregnane glycoside, named nizwaside whose structure was established using 1D and 2D NMR techniques as well as mass spectrometry (ESIMS). Nizwaside was tested for anticancer, DPPH antioxidant, urease enzyme inhibition, α-glucosidase enzyme inhibition and acetylcholinesterase inhibition activities. Interestingly, nizwaside showed significant anti-proliferative effects on MDA MB231 breast cancer cells with an IC50 of 23.5 µg/ml. Moreover, nizwaside was more effective than Doxorubicin, a well-known clinical anticancer drug, in suppressing MDA MB231 cell proliferation even at concentrations lower than that of Doxorubicin (75 µg/ml nizwaside vs. 100 µg/ml Doxorubicin). On the other hand, nizwaside showed relatively weak antioxidant activity with 15 % inhibition.

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Authors and Affiliations

  1. UoN Chair of Oman’s Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman

    Hidayat Hussain, Muhammad Adil Raees, Najeeb Ur Rehman, Ahmed Al-Rawahi, Husain Yar Khan, Ghulam Abbas, Mohammed Abdullah Al-Broumi & Ahmed Al-Harrasi

  2. Department of Chemistry, Federal Urdu University of Arts, Science and Technolgy, Karachi, Pakistan

    Muhammad Adil Raees & Talat Mahmood

  3. Organische Chemie, Martin-Luther Universität Halle-Wittenberg, Kurt-Mothes-Str. 2, 06120, Halle, Germany

    René Csuk

  4. Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa, 616, Sultanate of Oman

    Ghulam Abbas

  5. Department of Chemistry and Polymer Science, University of Stellenbosch, P/Bag X1, Matieland, 7602, South Africa

    Ivan R. Green

  6. DARIS Centre for Scientific Research and Technology Development, University of Nizwa, Birkat Al Mauz, P. O Box 33, 616, Nizwa, Sultanate of Oman

    Ali Elyassi

Authors
  1. Hidayat Hussain
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  2. Muhammad Adil Raees
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  3. Najeeb Ur Rehman
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  4. Ahmed Al-Rawahi
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  5. René Csuk
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  6. Husain Yar Khan
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  7. Ghulam Abbas
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  8. Mohammed Abdullah Al-Broumi
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  9. Ivan R. Green
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  10. Ali Elyassi
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  11. Talat Mahmood
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  12. Ahmed Al-Harrasi
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Corresponding authors

Correspondence to Hidayat Hussain or Ahmed Al-Harrasi.

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Hussain, H., Raees, M.A., Rehman, N.U. et al. Nizwaside: a new anticancer pregnane glycoside from the sap of Desmidorchis flava . Arch. Pharm. Res. 38, 2137–2142 (2015). https://doi.org/10.1007/s12272-015-0653-0

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  • DOI: https://doi.org/10.1007/s12272-015-0653-0

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