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Application of chemical biology in target identification and drug discovery

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Abstract

Drug discovery and development is vital to the well-being of mankind and sustainability of the pharmaceutical industry. Using chemical biology approaches to discover drug leads has become a widely accepted path partially because of the completion of the Human Genome Project. Chemical biology mainly solves biological problems through searching previously unknown targets for pharmacologically active small molecules or finding ligands for well-defined drug targets. It is a powerful tool to study how these small molecules interact with their respective targets, as well as their roles in signal transduction, molecular recognition and cell functions. There have been an increasing number of new therapeutic targets being identified and subsequently validated as a result of advances in functional genomics, which in turn led to the discovery of numerous active small molecules via a variety of high-throughput screening initiatives. In this review, we highlight some applications of chemical biology in the context of drug discovery.

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Acknowledgments

This work was partially supported by the National Health and Family Planning Commission (2012ZX09304-011, 2013ZX09401003-005, 2013ZX09507001 and 2013ZX09507-002), Shanghai Science and Technology Development Fund (13DZ2290300 and 15DZ2291600), the CAS-Novo Nordisk Research Fund and the Thousand Talents Program in China. It was inspired by the international and interdisciplinary environments of the JSPS Asian CORE Program, “Asian Chemical Biology Initiative”.

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  1. The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, 201203, China

    Yue Zhu, Ting Xiao, Saifei Lei, Fulai Zhou & Ming-Wei Wang

  2. School of Life Science and Technology, ShanghaiTech University, Shanghai, 200031, China

    Ming-Wei Wang

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Zhu, Y., Xiao, T., Lei, S. et al. Application of chemical biology in target identification and drug discovery. Arch. Pharm. Res. 38, 1642–1650 (2015). https://doi.org/10.1007/s12272-015-0643-2

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