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Role of sirtuins in chronic obstructive pulmonary disease

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An Erratum to this article was published on 15 January 2015

Abstract

Chronic obstructive pulmonary disease (COPD) is characterized by airflow limitation that is associated with chronic inflammatory response to noxious particles or gases. The airflow limitation may be explained by hypersecretion of mucus, thickening and fibrosis of small airways and alveolar wall destruction in emphysema. Sirtuins, a group of class III deacetylases, have gained considerable attention for their positive effects on aging-related disease, such as cancer, cardiovascular disease, neurodegenerative diseases, osteoporosis and COPD. Among the seven mammalian sirtuins, SIRT1–SIRT7, SIRT1 and SIRT6 are considered to have protective effects against COPD. In the lungs, SIRT1 inhibits autophagy, cellular senescence, fibrosis, and inflammation by deacetylation of target proteins using NAD+ as co-substrate and is therefore linked to the redox state. In addition to SIRT1, SIRT6 have also been shown to improve or slow down COPD. SIRT6 is associated with redox state and inhibits cellular senescence and fibrosis. Therefore, activation of SIRT1 and SIRT6 might be an attractive approach for novel therapeutic targets for COPD. The present review describes the protective effects of SIRT1 and SIRT6 against COPD and their target proteins involved in the pathophysiology of COPD.

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References

  • Amsellem, V., G. Gary-Bobo, E. Marcos, B. Maitre, V. Chaar, P. Validire, J.B. Stern, H. Noureddine, E. Sapin, D. Rideau, S. Hue, P. Le Corvoisier, S. Le Gouvello, J.L. Dubois-Randé, J. Boczkowski, and S. Adnot. 2011. Telomere dysfunction causes sustained inflammation in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 184: 1358–1366.

    CAS  PubMed  Google Scholar 

  • Aoshiba, K., F. Zhou, T. Tsuji, and A. Nagai. 2012. DNA damage as a molecular link in the pathogenesis of COPD in smokers. European Respiratory Journal 39: 1368–1376.

    CAS  PubMed  Google Scholar 

  • Araya, J., S. Cambier, J.A. Markovics, P. Wolters, D. Jablons, A. Hill, W. Finkbeiner, K. Jones, V.C. Broaddus, D. Sheppard, A. Barzcak, Y. Xiao, D.J. Erle, and S.L. Nishimura. 2007. Squamous metaplasia amplifies pathologic epithelial-mesenchymal interactions in COPD patients. The Journal of clinical investigation 117: 3551–3562.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Arunachalam, G., I.K. Sundar, J.W. Hwang, H. Yao, and I. Rahman. 2010. Emphysema is associated with increased inflammation in lungs of atherosclerosis-prone mice by cigarette smoke: Implications in comorbidities of COPD. Journal of Inflammation (London) 7: 34.

    Google Scholar 

  • Aquilano, K., P. Vigilanza, S. Baldelli, B. Pagliei, G. Rotilio, and M.R. Ciriolo. 2010. Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. Journal of Biological Chemistry 285: 21590–21599.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bao, J., and M.N. Sack. 2010. Protein deacetylation by sirtuins: Delineating a post-translational regulatory program responsive to nutrient and redox stressors. Cellular and Molecular Life Sciences 67: 3073–3087.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Bartkova, J., N. Rezaei, M. Liontos, P. Karakaidos, D. Kletsas, N. Issaeva, L.V. Vassiliou, E. Kolettas, K. Niforou, V.C. Zoumpourlis, M. Takaoka, H. Nakagawa, F. Tort, K. Fugger, F. Johansson, M. Sehested, C.L. Andersen, L. Dyrskjot, T. Ørntoft, J. Lukas, C. Kittas, T. Helleday, T.D. Halazonetis, J. Bartek, and V.G. Gorgoulis. 2006. Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints. Nature 444: 633–637.

    CAS  PubMed  Google Scholar 

  • Barnes, P.J. 2004. Alveolar macrophages as orchestrators of COPD. COPD 1: 59–70.

    PubMed  Google Scholar 

  • Blander, G., and L. Guarente. 2004. The Sir2 family of protein deacetylases. Annual Review of Biochemistry 73: 417–435.

    CAS  PubMed  Google Scholar 

  • Bonniaud, P., M. Kolb, T. Galt, J. Robertson, C. Robbins, M. Stampfli, C. Lavery, P.J. Margetts, A.B. Roberts, and J. Gauldie. 2004. Smad3 null mice develop airspace enlargement and are resistant to TGF-beta-mediated pulmonary fibrosis. J. Immunol. 173: 2099–2108.

    CAS  PubMed  Google Scholar 

  • Borra, M.T., B.C. Smith, and J.M. Denu. 2005. Mechanism of human SIRT1 activation by resveratrol. Journal of Biological Chemistry 280: 17187–17195.

    CAS  PubMed  Google Scholar 

  • Brooke, B.S., A. Bayes-Genis, and D.Y. Li. 2003. New insights into elastin and vascular disease. Trends in Cardiovascular Medicine 13: 176–181.

    CAS  PubMed  Google Scholar 

  • Caito, S., J.W. Hwang, S. Chung, H. Yao, I.K. Sundar, and I. Rahman. 2010. PARP-1 inhibition does not restore oxidant-mediated reduction in SIRT1 activity. Biochemical and Biophysical Research Communications 392: 264–270.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Cataldo, D., C. Munaut, A. Noël, F. Frankenne, P. Bartsch, J.M. Foidart, and R. Louis. 2000. MMP-2- and MMP-9-linked gelatinolytic activity in the sputum from patients with asthma and chronic obstructive pulmonary disease. International Archives of Allergy and Immunology 123: 259–267.

    CAS  PubMed  Google Scholar 

  • Chen, J., Y. Zhou, S. Mueller-Steiner, L.F. Chen, H. Kwon, S. Yi, L. Mucke, and L. Gan. 2005. SIRT1 protects against microglia-dependent amyloid-beta toxicity through inhibiting NF-kappaB signaling. Journal of Biological Chemistry 280: 40364–40374.

    CAS  PubMed  Google Scholar 

  • Chen, Z.H., H.P. Kim, F.C. Sciurba, S.J. Lee, C. Feghali-Bostwick, D.B. Stolz, R. Dhir, R.J. Landreneau, M.J. Schuchert, S.A. Yousem, K. Nakahira, J.M. Pilewski, J.S. Lee, Y. Zhang, S.W. Ryter, and A.M. Choi. 2008. Egr-1 regulates autophagy in cigarette smoke-induced chronic obstructive pulmonary disease. PLoS ONE 3: e3316.

    PubMed Central  PubMed  Google Scholar 

  • Cheng, H.L., R. Mostoslavsky, S. Saito, J.P. Manis, Y. Gu, P. Patel, R. Bronson, E. Appella, F.W. Alt, and K.F. Chua. 2003. Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice. Proceedings of the National Academy of Sciences 100: 10794–10799.

    CAS  Google Scholar 

  • Chrysofakis, G., G. Chrysofakis, N. Tzanakis, D. Kyriakoy, M. Tsoumakidou, I. Tsiligianni, M. Klimathianaki, and N.M. Siafakas. 2004. Perforin expression and cytotoxic activity of sputum CD8+ lymphocytes in patients with COPD. Chest 125: 71–76.

    PubMed  Google Scholar 

  • Costa, C., R. Rufino, S.L. Traves, E. Lapa, J.R. Silva, P.J. Barnes, and L.E. Donnelly. 2008. CXCR3 and CCR5 chemokines in the induced sputum from patients with COPD. Chest 133: 26–33.

    CAS  PubMed  Google Scholar 

  • Churg, A., S. Zhou, and J.L. Wright. 2012. Series matrix metalloproteinases in lung health and disease: Matrix metalloproteinases in COPD. European Respiratory Journal 39: 197–209.

    CAS  PubMed  Google Scholar 

  • de Boer, W.I., A. van Schadewijk, J.K. Sont, H.S. Sharma, J. Stolk, P.S. Hiemstra, and J.H. van Krieken. 1998. Transforming growth factor beta 1 and recruitment of macrophages and mast cells in airways in chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 158: 1951–1957.

    PubMed  Google Scholar 

  • de la Lastra, C.A., and I. Villegas. 2007. Resveratrol as an antioxidant and pro-oxidant agent: mechanisms and clinical implications. Biochemical Society Transactions 35: 1156–1160.

    PubMed  Google Scholar 

  • Deshmane, S.L., S. Kremlev, S. Amini, and B.E. Sawaya. 2009. Monocyte chemoattractant protein-1 (MCP-1): An overview. Journal of Interferon and Cytokine Research 29: 313–326.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Di Stefano, A., A. Capelli, M. Lusuardi, P. Balbo, C. Vecchio, P. Maestrelli, C.E. Mapp, L.M. Fabbri, C.F. Donner, and M. Saetta. 1998. Severity of airflow limitation is associated with severity of airway inflammation in smokers. American Journal of Respiratory and Critical Care Medicine 158: 1277–1285.

    PubMed  Google Scholar 

  • Dioum, E.M., R. Chen, M.S. Alexander, Q. Zhang, R.T. Hogg, R.D. Gerard, and J.A. Garcia. 2009. Regulation of hypoxia-inducible factor 2alpha signaling by the stress-responsive deacetylase sirtuin 1. Science 324: 1289–1293.

    CAS  PubMed  Google Scholar 

  • Du, J., H. Jiang, and H. Lin. 2009. Investigating the ADP-ribosyltransferase activity of sirtuins with NAD analogues and 32P-NAD. Biochemistry 48: 2878–2890.

    CAS  PubMed  Google Scholar 

  • Du, J., Y. Zhou, X. Su, J.J. Yu, S. Khan, H. Jiang, J. Kim, J. Woo, J.H. Kim, B.H. Choi, B. He, W. Chen, S. Zhang, R.A. Cerione, J. Auwerx, Q. Hao, and H. Lin. 2011. Sirt5 is a NAD-dependent protein lysine demalonylase and desuccinylase. Science 334: 806–809.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Frye, R.A. 2000. Phylogenetic classification of prokaryotic and eukaryotic Sir2-like proteins. Biochemical and Biophysical Research Communications 273: 793–798.

    CAS  PubMed  Google Scholar 

  • Furukawa, A., S. Tada-Oikawa, S. Kawanishi, and S. Oikawa. 2007. H2O2 accelerates cellular senescence by accumulation of acetylated p53 via decrease in the function of SIRT1 by NAD+ depletion. Cellular Physiology and Biochemistry 20: 45–54.

    CAS  PubMed  Google Scholar 

  • Ganesan, S., A.N. Faris, A.T. Comstock, S.S. Chattoraj, A. Chattoraj, J.R. Burgess, J.L. Curtis, F.J. Martinez, S. Zick, M.B. Hershenson, and U.S. Sajjan. 2010. Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression. Respiratory Research 11: 131.

    PubMed Central  PubMed  Google Scholar 

  • Gorgoulis, V.G., L.V. Vassiliou, P. Karakaidos, P. Zacharatos, A. Kotsinas, T. Liloglou, M. Venere, R.A. Ditullio Jr, N.G. Kastrinakis, B. Levy, D. Kletsas, A. Yoneta, M. Herlyn, C. Kittas, and T.D. Halazonetis. 2005. Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions. Nature 434: 907–913.

    CAS  PubMed  Google Scholar 

  • Gorospe, M., and R. de Cabo. 2008. As SIRTing the DNA damage response. Trends in Cell Biology 18: 77–83.

    CAS  PubMed  Google Scholar 

  • Gray, K., and M. Bennett. 2011. Role of DNA damage in atherosclerosis-Bystander or participant? Biochemical Pharmacology 82: 693–700.

    CAS  PubMed  Google Scholar 

  • Guarente, L., and H. Franklin. 2011. Epstein Lecture: Sirtuins, aging, and medicine. New England Journal of Medicine 364: 2235–2244.

    CAS  PubMed  Google Scholar 

  • Gueders, M.M., J.M. Foidart, A. Noel, and D.D. Cataldo. 2006. Matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs in the respiratory tract: potential implications in asthma and other lung diseases. European Journal of Pharmacology 533: 133–144.

    CAS  PubMed  Google Scholar 

  • Hageman, G.J., I. Larik, H.J. Pennings, G.R. Haenen, E.F. Wouters, and A. Bast. 2003. Systemic poly(ADP-ribose) polymerase-1 activation, chronic inflammation, and oxidative stress in COPD patients. Free Radical Biology and Medicine 35: 140–148.

    CAS  PubMed  Google Scholar 

  • Hallows, W.C., B.N. Albaugh, and J.M. Denu. 2008. Where in the cell is SIRT3?–functional localization of an NAD+-dependent protein deacetylase. Biochemical Journal 411: e11–e13.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hautamaki, R.D., D.K. Kobayashi, R.M. Senior, and S.D. Shapiro. 1997. Requirement for macrophage elastase for cigarette smoke-induced emphysema in mice. Science 277: 2002–2004.

    CAS  PubMed  Google Scholar 

  • Hsu, C.P., N. Hariharan, R.R. Alcendor, S. Oka, and J. Sadoshima. 2009. Nicotinamide phosphoribosyltransferase regulates cell survival through autophagy in cardiomyocytes. Autophagy 5: 1229–1231.

    CAS  PubMed  Google Scholar 

  • Huang, Q., Y.T. Wu, H.L. Tan, C.N. Ong, and H.M. Shen. 2009. A novel function of poly(ADP-ribose) polymerase-1 in modulation of autophagy and necrosis under oxidative stress. Cell Death and Differentiation 16: 264–277.

    CAS  PubMed  Google Scholar 

  • Huynh, M.L., V.A. Fadok, and P.M. Henson. 2002. Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta 1 secretion and the resolution of inflammation. The Journal of clinical investigation 109: 41–50.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hwang, J.W., S. Chung, I.K. Sundar, H. Yao, G. Arunachalam, M.W. McBurney, and I. Rahman. 2010. Cigarette smoke-induced autophagy is regulated by SIRT1-PARP-1-dependent mechanism: Implication in pathogenesis of COPD. Archives of Biochemistry and Biophysics 500: 203–209.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Hwang, J.W., H. Yao, S. Caito, I.K. Sundar, and I. Rahman. 2013. Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radical Biology and Medicine 61: 95–110.

    CAS  PubMed  Google Scholar 

  • Ilumets, H., P. Rytilä, I. Demedts, G.G. Brusselle, A. Sovijärvi, M. Myllärniemi, T. Sorsa, and V.L. Kinnula. 2007. Matrix metalloproteinases -8, -9 and -12 in smokers and patients with stage 0 COPD. International Journal of Chronic Obstructive Pulmonary Disease 2: 369–379.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kim, H.P., X. Wang, Z.H. Chen, S.J. Lee, M.H. Huang, Y. Wang, S.W. Ryter, and A.M. Choi. 2008. Autophagic proteins regulate cigarette smoke-induced apoptosis: Protective role of heme oxygenase-1. Autophagy 4: 887–895.

    CAS  PubMed  Google Scholar 

  • Kim, W., and J.E. Kim. 2013. SIRT7 an emerging sirtuin: Deciphering newer roles. Journal of Physiology and Pharmacology 64: 531–534.

    CAS  PubMed  Google Scholar 

  • Kitagawa, M., S.H. Lee, and F. McCormick. 2008. Skp2 suppresses p53-dependent apoptosis by inhibiting p300. Molecular Cell 29: 217–231.

    CAS  PubMed  Google Scholar 

  • Klionsky, D.J., and S.D. Emr. 2000. Autophagy as a regulated pathway of cellular degradation. Science 290: 1717–1721.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Knobloch, J., C. Wahl, M. Feldmann, D. Jungck, J. Strauch, E. Stoelben, and A. Koch. 2014. Resveratrol attenuates the release of inflammatory cytokines from human bronchial smooth muscle cells exposed to lipoteichoic acid in chronic obstructive pulmonary disease. Basic and Clinical Pharmacology and Toxicology 114: 202–209.

    CAS  PubMed  Google Scholar 

  • Kracikova, M., G. Akiri, A. George, R. Sachidanandam, and S.A. Aaronson. 2013. A threshold mechanism mediates p53 cell fate decision between growth arrest and apoptosis. Cell Death and Differentiation 20: 576–588.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Kunsch, C., and R.M. Medford. 1999. Oxidative stress as a regulator of gene expression in the vasculature. Circulation Research 85: 753–766.

    CAS  PubMed  Google Scholar 

  • Kurz, D.J., S. Decary, Y. Hong, E. Trivier, A. Akhmedov, and J.D. Erusalimsky. 2004. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. Journal of Cell Science 117: 2417–2426.

    CAS  PubMed  Google Scholar 

  • Landry, J., J.T. Slama, and R. Sternglanz. 2000. Role of NAD(+) in the deacetylase activity of the SIR2-like proteins. Biochemical and Biophysical Research Communications 278: 685–690.

    CAS  PubMed  Google Scholar 

  • Langley, E., M. Pearson, M. Faretta, U.M. Bauer, R.A. Frye, S. Minucci, P.G. Pelicci, and T. Kouzarides. 2002. Human SIR2 deacetylates p53 and antagonizes PML/p53-induced cellular senescence. EMBO Journal 21: 2383–2396.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lanzillotta, A., I. Sarnico, R. Ingrassia, F. Boroni, C. Branca, M. Benarese, G. Faraco, F. Blasi, A. Chiarugi, P. Spano, and M. Pizzi. 2010. The acetylation of RelA in Lys310 dictates the NF-κB-dependent response in post-ischemic injury. Cell Death and Disease 1: e96.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Lin, S.J., P.A. Defossez, and L. Guarente. 2000. Requirement of NAD and SIR2 for life-span extension by calorie restriction in Saccharomyces cerevisiae. Science 289: 2126–2128.

    CAS  PubMed  Google Scholar 

  • Liszt, G., E. Ford, M. Kurtev, and L. Guarente. 2005. Mouse Sir2 homolog SIRT6 is a nuclear ADP-ribosyltransferase. Journal of Biological Chemistry 280: 21313–21320.

    CAS  PubMed  Google Scholar 

  • Luo, J., A.Y. Nikolaev, S. Imai, D. Chen, F. Su, A. Shiloh, L. Guarente, and W. Gu. 2001. Negative control of p53 by Sir2alpha promotes cell survival under stress. Cell 107: 137–148.

    CAS  PubMed  Google Scholar 

  • Maclay, J.D., D.A. McAllister, R. Rabinovich, I. Haq, S. Maxwell, S. Hartland, M. Connell, J.T. Murchison, E.J. van Beek, R.D. Gray, N.L. Mills, and W. Macnee. 2012. Systemic elastin degradation in chronic obstructive pulmonary disease. Thorax 67: 606–612.

    PubMed  Google Scholar 

  • MacNee, W. 2001. Oxidative stress and lung inflammation in airways disease. European Journal of Pharmacology 429: 195–207.

    CAS  PubMed  Google Scholar 

  • Majo, J., H. Ghezzo, and M.G. Cosio. 2001. Lymphocyte population and apoptosis in the lungs of smokers and their relation to emphysema. European Respiratory Journal 17: 946–953.

    CAS  PubMed  Google Scholar 

  • Manoury, B., S. Nenan, I. Guénon, V. Lagente, and E. Boichot. 2007. Influence of early neutrophil depletion on MMPs/TIMP-1 balance in bleomycin-induced lung fibrosis. International Immunopharmacology 7: 900–911.

    CAS  PubMed  Google Scholar 

  • McAllister, D.A., J.D. Maclay, N.L. Mills, G. Mair, J. Miller, D. Anderson, D.E. Newby, J.T. Murchison, and W. Macnee. 2007. Arterial stiffness is independently associated with emphysema severity in patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 176: 1208–1214.

    PubMed Central  PubMed  Google Scholar 

  • McCord, R.A., E. Michishita, T. Hong, E. Berber, L.D. Boxer, R. Kusumoto, S. Guan, X. Shi, O. Gozani, A.L. Burlingame, V.A. Bohr, and K.F. Chua. 2009. SIRT6 stabilizes DNA-dependent Protein Kinase at chromaitn for DNA double-strnad break repair. Aging 1: 109–121.

    CAS  PubMed Central  PubMed  Google Scholar 

  • McDonough, J.E., R. Yuan, M. Suzuki, N. Seyednejad, W.M. Elliott, P.G. Sanchez, A.C. Wright, W.B. Gefter, L. Litzky, H.O. Coxson, P.D. Paré, D.D. Sin, R.A. Pierce, J.C. Woods, A.M. McWilliams, J.R. Mayo, S.C. Lam, J.D. Cooper, and J.C. Hogg. 2011. Small-airway obstruction and emphysema in chronic obstructive pulmonary disease. New England Journal of Medicine 365: 1567–1575.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mercer, B.A., N. Kolesnikova, J. Sonett, and J. D’Armiento. 2004. Extracellular regulated kinase/mitogen activated protein kinase is up-regulated in pulmonary emphysema and mediates matrix metalloproteinase-1 induction by cigarette smoke. Journal of Biological Chemistry 279: 17690–17696.

    CAS  PubMed  Google Scholar 

  • Minagawa, S., J. Araya, T. Numata, S. Nojiri, H. Hara, Y. Yumino, M. Kawaishi, M. Odaka, T. Morikawa, S.L. Nishimura, K. Nakayama, and K. Kuwano. 2011. Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells. American Journal of Physiology. Lung Cellular and Molecular Physiology 300: L391–L401.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Michan, S., and D. Sinclair. 2007. Sirtuins in mammals: Insights into their biological function. Biochemical Journal 404: 1–13.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Michishita, E., J.Y. Park, J.M. Burneskis, J.C. Barrett, and I. Horikawa. 2005. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Molecular Biology of the Cell 16: 4623–4635.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Mostoslavsky, R., K.F. Chua, D.B. Lombard, W.W. Pang, M.R. Fischer, L. Gellon, P. Liu, G. Mostoslavsky, S. Franco, M.M. Murphy, K.D. Mills, P. Patel, J.T. Hsu, A.L. Hong, E. Ford, H.L. Cheng, C. Kennedy, N. Nunez, R. Bronson, D. Frendewey, W. Auerbach, D. Valenzuela, M. Karow, M.O. Hottiger, S. Hursting, J.C. Barrett, L. Guarente, R. Mulligan, B. Demple, G.D. Yancopoulos, and F.W. Alt. 2006. Genomic instability and aginglike phenotype in the absence of mammalian SIRT6. Cell 124: 315–329.

    CAS  PubMed  Google Scholar 

  • Murphy, G., and A.J. Docherty. 1992. The matrix metalloproteinases and their inhibitors. American Journal of Respiratory Cell and Molecular Biology 7: 120–125.

    CAS  PubMed  Google Scholar 

  • Nakamaru, Y., C. Vuppusetty, H. Wada, J.C. Milne, M. Ito, C. Rossios, M. Elliot, J. Hogg, S. Kharitonov, H. Goto, J.E. Bemis, P. Elliott, P.J. Barnes, and K. Ito. 2009. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. The FASEB Journal 23: 2810–2819.

    CAS  Google Scholar 

  • North, B.J., and E. Verdin. 2007. Interphase nucleocytoplasmic shuttling and localization of SIRT2 during mitosis. PLoS ONE 2: e784.

    PubMed Central  PubMed  Google Scholar 

  • Ogata, M., S. Hino, A. Saito, K. Morikawa, S. Kondo, S. Kanemoto, T. Murakami, M. Taniguchi, I. Tanii, K. Yoshinaga, S. Shiosaka, J.A. Hammarback, F. Urano, and K. Imaizumi. 2006. Autophagy is activated for cell survival after endoplasmic reticulum stress. Molecular and Cellular Biology 26: 9220–9231.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Oit-Wiscombe, I., L. Virag, U. Soomets, and A. Altraja. 2013. Increased DNA damage in progression of COPD: a response by poly(ADP-ribose) polymerase-1. PLoS ONE 8: e70333.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Ota, H., M. Akishita, M. Eto, K. Iijima, M. Kaneki, and Y. Ouchi. 2007. Sirt1 modulates premature senescence-like phenotype in human endothelial cells. Journal of Molecular and Cellular Cardiology 43: 571–579.

    CAS  PubMed  Google Scholar 

  • Paschalaki, K.E., R.D. Starke, Y. Hu, N. Mercado, A. Margariti, V.G. Gorgoulis, A.M. Randi, and P.J. Barnes. 2013. Dysfunction of endothelial progenitor cells from smokers and chronic obstructive pulmonary disease patients due to increased DNA damage and senescence. Stem Cells 31: 2813–2826.

    CAS  PubMed  Google Scholar 

  • Peng, C., Lu, Z., Xie, Z., Cheng, Z., Chen, Y., Tan, M., Luo, H., Zhang, Y., He, W., Yang, K., Zwaans, B.M., Tishkoff, D., Ho, L., Lombard, D., He, T.C., Dai, J., Verdin, E., Ye, Y., and Y. Zhao. 2011. The first identification of lysine malonylation substrates and its regulatory enzyme. Molecular of Cell Proteomics. 10: M111.012658.

  • Pulliero, A., A. Seydel, A. Camoirano, S.C. Saccà, M. Sandri, and A. Izzotti. 2014. Oxidative damage and autophagy in the human trabecular meshwork as related with ageing. PLoS ONE 9: e98106.

    PubMed Central  PubMed  Google Scholar 

  • Qian, B.Z., J. Li, H. Zhang, T. Kitamura, J. Zhang, L.R. Campion, E.A. Kaiser, L.A. Snyder, and J.W. Pollard. 2011. CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis. Nature 475: 222–225.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Rahman, I., and W. MacNee. 1998. Role of transcription factors in inflammatory lung diseases. Thorax 53: 601–612.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Rajendrasozhan, S., S.R. Yang, V.L. Kinnula, and I. Rahman. 2008. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 177: 861–870.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Saetta, M., M. Mariani, P. Panina-Bordignon, G. Turato, C. Buonsanti, S. Baraldo, C.M. Bellettato, A. Papi, L. Corbetta, R. Zuin, F. Sinigaglia, and L.M. Fabbri. 2002. Increased expression of the chemokine receptor CXCR3 and its ligand CXCL10 in peripheral airways of smokers with chronic obstructive pulmonary disease. American Journal of Respiratory and Critical Care Medicine 165: 1404–1409.

    PubMed  Google Scholar 

  • Sauve, A.A., C. Wolberger, V.L. Schramm, and J.D. Boeke. 2006. The biochemistry of sirtuins. Annual Review of Biochemistry 75: 435–465.

    CAS  PubMed  Google Scholar 

  • Scher, M.B., A. Vaquero, and D. Reinberg. 2007. SirT3 is a nuclear NAD+-dependent histone deacetylase that translocates to the mitochondria upon cellular stress. Genes and Development 21: 920–928.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schlereth, K., J.P. Charles, A.C. Bretz, and T. Stiewe. 2010. Life or death: 53-induced apoptosis requires DNA binding cooperativity. Cell Cycle 9: 4068–4076.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schug, T.T., Q. Xu, H. Gao, A. Peres-da-Silva, D.W. Draper, M.B. Fessler, A. Purushotham, and X. Li. 2010. Myeloid deletion of SIRT1 induces inflammatory signaling in response to environmental stress. Molecular and Cellular Biology 30: 4712–4721.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Schwer, B., and E. Verdin. 2008. Conserved metabolic regulatory functions of sirtuins. Cell Metabolism 7: 104–112.

    CAS  PubMed  Google Scholar 

  • Shi, J., N. Yin, L.L. Xuan, C.S. Yao, A.M. Meng, and Q. Hou. 2012. Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy. Acta Pharmacologica Sinica 33: 888–896.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Shi, Y., G.G. Camici, and T.F. Lüscher. 2010. Cardiovascular determinants of life span. Pflugers Archiv European Journal of Physiology 459: 315–324.

    CAS  PubMed  Google Scholar 

  • Shifren, A., and R.P. Mecham. 2006. The stumbling block in lung repair of emphysema: Elastic fiber assembly. Proceedings of the American Thoracic Society 3: 428–433.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Siedlinski, M., J.M. Boer, H.A. Smit, D.S. Postma, and H.M. Boezen. 2012. Dietary factors and lung function in the general population: Wine and resveratrol intake. European Respiratory Journal 39: 385–391.

    CAS  PubMed  Google Scholar 

  • Sime, P.J., Z. Xing, F.L. Graham, K.G. Csaky, and J. Gauldie. 1997. Adenovector-mediated gene transfer of active transforming growth factor-β 1 induces prolonged severe fibrosis in rat lung. Journal of Clinical Investigation 100: 768–776.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Sommerhoff, C.P., J.A. Nadel, C.B. Basbaum, and G.H. Caughey. 1990. Neutrophil elastase and cathepsin G stimulate secretion from cultured bovine airway gland serous cells. Journal of Clinical Investigation 85: 682–689.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Stein, S., N. Schafer, A. Breitenstein, C. Besler, S. Winnik, C. Lohmann, K. Heinrich, C.E. Brokopp, C. Handschin, U. Landmesser, F.C. Tanner, T.F. Lüscher, and C.M. Matter. 2010. SIRT1 reduces endothelial activation without affecting vascular function in ApoE-/- mice. Aging 2: 353–360.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Takasaka, N., J. Araya, H. Hara, S. Ito, K. Kobayashi, Y. Kurita, H. Wakui, Y. Yoshii, Y. Yumino, S. Fujii, S. Minagawa, C. Tsurushige, J. Kojima, T. Numata, K. Shimizu, M. Kawaishi, Y. Kaneko, N. Kamiya, J. Hirano, M. Odaka, T. Morikawa, S.L. Nishimura, K. Nakayama, and K. Kuwano. 2014. Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. Journal of Immunology 192: 958–968.

    CAS  Google Scholar 

  • Takeyama, K., C. Agusti, I. Ueki, J. Lausier, L.O. Cardell, and J.A. Nadel. 1998. Neutrophil-dependent goblet cell degranulation: role of membrane-bound elastase and adhesion molecules. American Journal of Physiology 275: L294–L302.

    CAS  PubMed  Google Scholar 

  • Takizawa, H., M. Tanaka, K. Takami, T. Ohtoshi, K. Ito, M. Satoh, Y. Okada, F. Yamasawa, K. Nakahara, and A. Umeda. 2001. Increased expression of transforming growth factor-beta 1 in small airway epithelium from tobacco smokers and patients with chronic obstructive pulmonary disease (COPD). American Journal of Respiratory and Critical Care Medicine 163: 1476–1483.

    CAS  PubMed  Google Scholar 

  • Tang, Y., J. Xu, W. Qu, X. Peng, P. Xin, X. Yang, C. Ying, X. Sun, and L. Hao. 2012. Resveratrol reduces vascular cell senescence through attenuation of oxidative stress by SIRT1/NADPH oxidase-dependent mechanisms. Journal of Nutritional Biochemistry 23: 1410–1416.

    CAS  PubMed  Google Scholar 

  • Tanner, K.G., J. Landry, R. Sternglanz, and J.M. Denu. 2000. Silent information regulator 2 family of NAD- dependent histone/protein deacetylases generates a unique product, 1-O-acetyl-ADP-ribose. Proceedings of the National Academy of Sciences USA 97: 14178–14182.

    CAS  Google Scholar 

  • Tanno, M., J. Sakamoto, T. Miura, K. Shimamoto, and Y. Horio. 2007. Nucleocytoplasmic shuttling of the NAD+-dependent histone deacetylase SIRT1. Journal of Biological Chemistry 282: 6823–6832.

    CAS  PubMed  Google Scholar 

  • Tennen, R.I., E. Berber, and K.F. Chua. 2010. Functional dissection of SIRT6: identification of domains that regulate histone deacetylase activity and chromatin localization. Mechanisms of Ageing and Development 131: 185–192.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Traves, S.L., S.J. Smith, P.J. Barnes, and L.E. Donnelly. 2004. Specific CXC but not CC chemokines cause elevated monocyte migration in COPD: A role for CXCR2. Journal of Leukocyte Biology 76: 441–450.

    CAS  PubMed  Google Scholar 

  • Tsuji, T., K. Aoshiba, and A. Nagai. 2010. Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease. Respiration 80: 59–70.

    PubMed  Google Scholar 

  • Vakhrusheva, O., C. Smolka, P. Gajawada, S. Kostin, T. Boettger, T. Kubin, T. Braun, and E. Bober. 2008. Sirt7 increases stress resistance of cardiomyocytes and prevents apoptosis and inflammatory cardiomyopathy in mice. Circulation Research 102: 703–710.

    CAS  PubMed  Google Scholar 

  • Verdin, E., M.D. Hirschey, L.W. Finley, and M.C. Haigis. 2010. Sirtuin regulation of mitochondria: Energy production, apoptosis, and signaling. Trends in Biochemical Sciences 35: 669–675.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Wang, F., M. Nguyen, F.X. Qin, and Q. Tong. 2007. SIRT2 deacetylates FOXO3a in response to oxidative stress and caloric restriction. Aging Cell 6: 505–514.

    CAS  PubMed  Google Scholar 

  • Wang, J.C., and M. Bennett. 2012. Aging and atherosclerosis: Mechanisms, functional consequences, and potential therapeutics for cellular senescence. Circulation Research 111: 245–259.

    CAS  PubMed  Google Scholar 

  • Wilson, M.S., S.K. Madala, T.R. Ramalingam, B.R. Gochuico, I.O. Rosas, A.W. Cheever, and T.A. Wynn. 2010. Bleomycin and IL-1beta-mediated pulmonary fibrosis is IL-17A dependent. Journal of Experimental Medicine 207: 535–552.

    CAS  PubMed Central  PubMed  Google Scholar 

  • World Health Organization. The 10 leading causes of death in the world, 2000 and 2012. http://who.int/mediacentre/factsheets/fs310/en/. Accessed 15 July 2014.

  • Xu, B., H. Chen, W. Xu, W. Zhang, S. Buckley, S.G. Zheng, D. Warburton, M. Kolb, J. Gauldie, and W. Shi. 2012. Molecular mechanisms of MMP9 overexpression and its role in emphysema pathogenesis of Smad3-deficient mice. American Journal of Physiology Lung Cellular and Molecular Physiology 303: L89–L96.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yadav, U.C., and K.V. Ramana. 2013. Regulation of NF-κB-induced inflammatory signaling by lipid peroxidation-derived aldehydes. Oxidative Medicine Cellular Longevity 2013: 690545.

    PubMed Central  PubMed  Google Scholar 

  • Yang, S.R., J. Wright, M. Bauter, K. Seweryniak, A. Kode, and I. Rahman. 2007. Sirtuin regulates cigarette smoke-induced proinflammatory mediator release via RelA/p65 NF-kappaB in macrophages in vitro and in rat lungs in vivo: Implications for chronic inflammation and aging. American Journal of Physiology Lung Cellular of Molecular 292: L567–L576.

    CAS  Google Scholar 

  • Yao, H., and I. Rahman. 2011. Current concepts on oxidative/carbonyl stress, inflammation and epigenetics in pathogenesis of chronic obstructive pulmonary disease. Toxicology and Applied Pharmacology 254: 72–85.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yao, H., S. Chung, J.W. Hwang, S. Rajendrasozhan, I.K. Sundar, D.A. Dean, M.W. McBurney, L. Guarente, W. Gu, M. Rönty, V.L. Kinnula, and I. Rahman. 2012. SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. Journal of Clinical Investigation 122: 2032–2045.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yao, H., J.W. Hwang, I.K. Sundar, A.E. Friedman, M.W. McBurney, L. Guarente, W. Gu, V.L. Kinnula, and I. Rahman. 2013. SIRT1 redresses the imbalance of tissue inhibitor of matrix metalloproteinase-1 and matrix metalloproteinase-9 in the development of mouse emphysema and human COPD. American Journal of Physiology Lung Cellular and Molecular Physiology 305: L615–L624.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yeung, F., J.E. Hoberg, C.S. Ramsey, M.D. Keller, D.R. Jones, R.A. Frye, and M.W. Mayo. 2004. Modulation of NF-kappaB-dependent transcription and cell survival by the SIRT1 deacetylase. EMBO Journal 23: 2369–2380.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yoshizaki, T., S. Schenk, T. Imamura, J.L. Babendure, N. Sonoda, E.J. Bae, D.Y. Oh, M. Lu, J.C. Milne, C. Westphal, G. Bandyopadhyay, and J.M. Olefsky. 2010. SIRT1 inhibits inflammatory pathways in macrophages and modulates insulin sensitivity. American Journal of Physiology-Endocrinology and Metabolism 298: E419–E428.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Yuan, Z., X. Zhang, N. Sengupta, W.S. Lane, and E. Seto. 2007. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Molecular Cell 27: 149–162.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zheng, T., Z. Zhu, Z. Wang, R.J. Homer, B. Ma, R.J. Riese Jr, H.A. Chapman Jr, S.D. Shapiro, and J.A. Elias. 2000. Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase- and cathepsin-dependent emphysema. Journal of Clinical Investigation 106: 1081–1093.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Zieman, S.J., V. Melenovsky, and D.A. Kass. 2005. Mechanisms, pathophysiology, and therapy of arterial stiffness. Arteriosclerosis Thrombosis and Vascular Biology 25: 932–943.

    CAS  Google Scholar 

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This work was supported by the 2012 Inje University research grant.

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  1. College of Pharmacy, Inje University, 197 Inje-ro, Gimhae, Gyeongnam, 621-749, Korea

    Pusoon Chun

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Chun, P. Role of sirtuins in chronic obstructive pulmonary disease. Arch. Pharm. Res. 38, 1–10 (2015). https://doi.org/10.1007/s12272-014-0494-2

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