Skip to main content
SpringerLink
Log in

Five new anthraquinones from the seed of Cassia obtusifolia

  • Research Article
  • Published:
Archives of Pharmacal Research Aims and scope Submit manuscript

Abstract

A phytochemical investigation on the seeds of Cassia obtusifolia led to the isolation of five new anthraquinones, including one aglycon and four glycosides. The structures were elucidated by analysis of extensive spectroscopic data and the results of acid hydrolysis. All these isolates were evaluated for their inhibitory effects against α-glucosidase, and 1 showed potent activity with IC50 value of 185 ± 15 µM.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  • Atta-ur-Rahman, Z.S., M.I. Choudhary, M.N. Akhtar, and S.N. Khan. 2008. α-Glucosidase inhibitory activity of triterpenoids from Cichorium intybus. Journal of Nature Product 71: 910–913.

    Article  CAS  Google Scholar 

  • Feng, J., X.-W. Yang, and R.-F. Wang. 2011. Bio-assay guided isolation and identification of α-glucosidase inhibitors from the leaves of Aquilaria sinensis. Phytochemistry 72: 242–247.

    Article  CAS  PubMed  Google Scholar 

  • Hao, Y.-J., Y.-L. Sang, and Y.-Q. Zhao. 2001. Chinese traditional herbal. Drugs 32: 858–859.

    CAS  Google Scholar 

  • Jin, Y.-N., P.-P. Li, X.-G. Li, J. Huang, and X. Chen. 2012. Effect of the extraction from Semen Cassiae on oxidative stress in diabetic mice. China Modern Medicine 19: 25–26.

    Google Scholar 

  • Joshi, H., and V.P. Kapoor. 2003. Cassia grandis Linn. Seed galactomannan: structural and crystallographical studies. Carbohydrate Research 38: 123–1907.

    Google Scholar 

  • Kim, Y.S., D.H. Jung, E. Sohn, Y.M. Lee, C.-S. Kim, and J.S. Kim. 2013. Extract of Cassiae semen attenuates diabetic nephropathy via inhibition of advanced glycation end products accumulation in streptozotocin-induced diabetic rats. Phytomedicine. doi:10.1016/j.phymed.2013.11.002.

    Google Scholar 

  • Li, G.-L., J.-Y. He, A. Zhang, Y. Wan, B. Wang, and W.-H. Chen. 2011. Toward potent α-glucosidase inhibitors based on xanthones: a closer look into the structure–activity correlations. European Journal of Medicinal Chemistry 46: 4050–4055.

  • Rizvi, S., S.C. Varshney, S.L. Abbas, and N. Jahan. 1972. Structure of nodolidate from the flowers of Cassia nodosa. Phytochemistry 11: 1823–1826.

    Article  CAS  Google Scholar 

  • Tang, L.-Y., Z.-J. Wang, M.-H. Fu, Y. He, H.-W. Wu, and L.-Q. Huang. 2008. A new anthraquinone glycoside from seeds of Cassia obtusifolia. Chinese Chemical Letters 19: 1083–1085.

    Article  CAS  Google Scholar 

  • Thilagam, E., B. Parimaladevi, C. Kumarappan, and S.C. Mandal. 2013. α-Glucosidase and α-amylase inhibitory activity of Senna surattensis. Journal of Acupuncture and Meridian Studies 6: 24–30.

    Article  PubMed  Google Scholar 

Download references

Acknowledgments

This work was financially supported by National Natural Science Foundation of China (No. 81173552).

Author information

Authors and Affiliations

  1. Institute of Traditional Chinese Materia Madica, Chinese Academy of Chinese Medical Sciences, Beijing, 100700, People’s Republic of China

    Yi-Long Xu, Li-Ying Tang, Xi-Dan Zhou, Guo-Hong Zhou & Zhu-Ju Wang

Authors
  1. Yi-Long Xu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Li-Ying Tang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Xi-Dan Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Guo-Hong Zhou
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Zhu-Ju Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Zhu-Ju Wang.

Additional information

Yi-Long Xu and Li-Ying Tang contributed equally to this work.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Xu, YL., Tang, LY., Zhou, XD. et al. Five new anthraquinones from the seed of Cassia obtusifolia . Arch. Pharm. Res. 38, 1054–1058 (2015). https://doi.org/10.1007/s12272-014-0462-x

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s12272-014-0462-x

Keywords

Search

Navigation