Abstract
One new 1,10-secoeudesmanolide (1), two eudesmanolides (2 and 3), together with nine known compounds (4–12) were isolated from the aerial parts of Inula britannica. The structures of the new compounds were elucidated by detailed spectroscopic analysis, including HRESIMS and 2D-NMR spectroscopic method. In addition, compounds 1–4 were tested for their inhibitory effects against LPS-induced NO production in RAW264.7 macrophages.
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Acknowledgments
The work was supported by program NCET Foundation, NSFC (81230090 and 81102778), partially supported by Global Research Network for Medicinal Plants (GRNMP) and King Saud University, Shanghai Leading Academic Discipline Project (B906), FP7-PEOPLE-IRSES-2008 (TCMCANCER Project 230232), Key laboratory of drug research for special environments, PLA, Shanghai Engineering Research Center for the Preparation of Bioactive Natural Products (10DZ2251300) and the Scientific Foundation of Shanghai China (10DZ1971700, 12401900501). National Major Project of China (2011ZX09307-002-03 and 2011ZX09102-006-02). National Key Technology R&D Program of China (2012BAI29B06).
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Xu-Feng Zhang and Jing-Ling Du have contributed equally to this work.
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Zhang, XF., Du, JL., Ren, J. et al. Three new sesquiterpene lactones from Inula britannica . Arch. Pharm. Res. 38, 666–672 (2015). https://doi.org/10.1007/s12272-014-0388-3
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DOI: https://doi.org/10.1007/s12272-014-0388-3