Archives of Pharmacal Research

, Volume 37, Issue 1, pp 43–52

Carbon-based drug delivery carriers for cancer therapy

  • Dong-Jin Lim
  • Myeongbu Sim
  • Leeseul Oh
  • Kyunghee Lim
  • Hansoo Park
Review

DOI: 10.1007/s12272-013-0277-1

Cite this article as:
Lim, D., Sim, M., Oh, L. et al. Arch. Pharm. Res. (2014) 37: 43. doi:10.1007/s12272-013-0277-1

Abstract

In the search to improve anticancer therapies, several drug carriers, including carbon-based nanomaterials have been studied. Both liposomes and polymeric microspheres have been used in anticancer drugs. However, there remains an on-going need for better therapeutic materials that have good drug solubility, an ability to reduce systemic toxicity through specific-tumor targeting, and rapid clearance. In this regard, carbon allotropes such as graphene oxide (GOs), carbon nanotubes (CNTs), and nanodiamonds (NDs), have been investigated, as they possess sufficient surface-to-volume ratio, thermal conductivity, rigid structural properties capable of post-chemical modification, and excellent biocompatibility. This review is aimed at exploring these carbon-based nanomaterials for use as multifaceted cancer drug carriers and is intended to demonstrate that GOs, CNTs, and NDs are likely to improve chemotherapeutical strategy for cancers in either a sole or combinational manner.

Keywords

NanodiamondsGraphene oxideCarbon nanotubeDrug delivery

Copyright information

© The Pharmaceutical Society of Korea 2013

Authors and Affiliations

  • Dong-Jin Lim
    • 1
  • Myeongbu Sim
    • 3
  • Leeseul Oh
    • 2
  • Kyunghee Lim
    • 2
  • Hansoo Park
    • 3
  1. 1.Department of Biomedical EngineeringUniversity of Alabama at BirminghamBirminghamUSA
  2. 2.School of Chemical EngineeringChung-Ang UniversitySeoulKorea
  3. 3.School of Integrative EngineeringChung-Ang UniversitySeoulKorea