Abstract
What would you do if your body decided to die when you were not ready? It appears that some biological program can shut down all bodily functions, in much the same way as apoptosis does so at the cellular level. Pacific salmon and annual cicada die after reproduction. How do they die chemically? Their programmed death after reproduction should have chemical signals. Similarly, pro-inflammatory cytokines, particularly tumor necrosis factor-α and interleukin-1β, could induce death in mammals. Acute massive production of them in sepsis and chronic tiny production in aging could lead to death. Thus, the mechanism of the whole body suicide program could be determined and some people could be rescued from this type of death by elucidating the death program. I propose that the concept of whole body apoptosis, defined as programmed whole body death, be adopted by scientific community.
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Baker, D.M., B. Davies, W.W. Dickhoff, and P. Swanson. 2000. Insulin-like growth factor I increases follicle-stimulating hormone (FSH) content and gonadotropin-releasing hormone-stimulated FSH release from coho salmon pituitary cells in vitro. Biology of Reproduction 63(3): 865–871.
Bernard, A.M., and G.R. Bernard. 2012. The immune response: targets for the treatment of severe sepsis. International journal of inflammation 2012: 697592.
Chan, J.L., K. Heist, A.M. DePaoli, J.D. Veldhuis, and C.S. Mantzoros. 2003. The role of falling leptin levels in the neuroendocrine and metabolic adaptation to short-term starvation in healthy men. The Journal of Clinical Investigation 111(9): 1409–1421.
Chung, H.Y., E.K. Lee, Y.J. Choi, J.M. Kim, D.H. Kim, Y. Zou, C.H. Kim, J. Lee, H.S. Kim, N.D. Kim, J.H. Jung, and B.P. Yu. 2011. Molecular inflammation as an underlying mechanism of the aging process and age-related diseases. Journal of Dental Research 90(7): 830–840.
Cui, B., Q. He, K. Zhang, and X. Chen. 2011. Determinants of annual-perennial plant zonation across a salt-fresh marsh interface: a multistage assessment. Oecologia 166(4): 1067–1075.
Fraser, D.A., J. Thoen, S. Bondhus, M. Haugen, J.E. Reseland, O. Djoseland, O. Forre, and J. Kjeldsen-Kragh. 2000. Reduction in serum leptin and IGF-1 but preserved T-lymphocyte numbers and activation after a ketogenic diet in rheumatoid arthritis patients. Clinical and Experimental Rheumatology 18(2): 209–214.
Fry, D.E. 2012. Sepsis, systemic inflammatory response, and multiple organ dysfunction: the mystery continues. The American surgeon 78(1): 1–8.
Hardie, D.G. 2004. The AMP-activated protein kinase pathway–new players upstream and downstream. Journal of Cell Science 117(Pt 23): 5479–5487.
Jones, M.W., and J.A. Hutchings. 2001. The influence of male parr body size and mate competition on fertilization success and effective population size in Atlantic salmon. Heredity 86(Pt 6): 675–684.
Kale, S.S., and S. Yende. 2011. Effects of aging on inflammation and hemostasis through the continuum of critical illness. Aging and disease 2(6): 501–511.
Lindberg, N., M. Virkkunen, P. Tani, B. Appelberg, R. Rimon, and T. Porkka-Heiskanen. 2003. Growth hormone-insulin-like growth factor-1 axis, leptin and sleep in anorexia nervosa patients. Neuropsychobiology 47(2): 78–85.
Lu, J.Y., N. Sadri, and R.J. Schneider. 2006. Endotoxic shock in AUF1 knockout mice mediated by failure to degrade proinflammatory cytokine mRNAs. Genes & Development 20(22): 3174–3184.
Mommsen, T.P. 2004. Salmon spawning migration and muscle protein metabolism: the August Krogh principle at work. Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 139(3): 383–400.
Namas, R., R. Zamora, G. An, J. Doyle, T.E. Dick, F.J. Jacono, I.P. Androulakis, G.F. Nieman, S. Chang, T.R. Billiar, J.A. Kellum, D.C. Angus, and Y. Vodovotz. 2012. Sepsis: something old, something new, and a systems view. Journal of critical care 27(3): 314.e1–314.e11.
Semeraro, N., C.T. Ammollo, F. Semeraro, and M. Colucci. 2012. Sepsis, thrombosis and organ dysfunction. Thrombosis Research 129(3): 290–295.
Taleux, N., I. De Potter, C. Deransart, G. Lacraz, R. Favier, X.M. Leverve, L. Hue, and B. Guigas. 2008. Lack of starvation-induced activation of AMP-activated protein kinase in the hypothalamus of the Lou/C rats resistant to obesity. International Journal of Obesity (London) 32(4): 639–647.
Ulukaya, E., C. Acilan, and Y. Yilmaz. 2011. Apoptosis: why and how does it occur in biology? Cell Biochemistry and Function 29(6): 468–480.
Yamashita, M., and S. Konagaya. 1991. Increase in catheptic activity and appearance of phagocytes in the white muscle of chum salmon during spawning migration. Biomedica Biochimica Acta 50(4–6): 565–567.
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This work was supported by the MRC program of the National Research Foundation of Korea funded by the Korea government (MEST)(grant no. 2009-0083538).
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Im, DS. How to die chemically? whole body apoptosis. Arch. Pharm. Res. 36, 919–921 (2013). https://doi.org/10.1007/s12272-013-0122-6
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DOI: https://doi.org/10.1007/s12272-013-0122-6