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Three new nor-dammarane triterpenoids from Dysoxylum hainanense with particular cytotoxicity against glioma cell line

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Abstract

Three new nor-dammarane triterpenoids, 12β-O-acetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (1), 12β,28-O-diacetyl-15α-hydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (2), 12β-hydoxy-3,15-dioxo-20,21,22-23,24,25,26,27-octanordammanran (3), together with one known compound, 12β-O-acetyl-15α,28-dihydoxy-3-oxo-17-en-20,21,22-23,24,25,26,27-octanordammanran (4), were isolated from the 95 % EtOH extract of Dysoxylum hainanense. The structures of the new compounds were elucidated by spectral methods. All the triterpenoids were in vitro evaluated for their cytotoxic activities against four tumor cell lines (BGC-823, U251, HepG2 and SGC-7901). All the three nor-dammarane triterpenoids exhibited particular significant cytotoxic activities against glioma cell line.

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Authors and Affiliations

  1. Department of Neurosurgery, Shenyang Northern Hospital, #83 Wenhua Road, Shenhe district, Shenyang, 110018, Liaoning Province, People’s Republic of China

    Peng Cao, Guobiao Liang, Xu Gao, Xiaogang Wang & Zhiqing Li

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  1. Peng Cao
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  2. Guobiao Liang
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  3. Xu Gao
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  4. Xiaogang Wang
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  5. Zhiqing Li
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Correspondence to Peng Cao.

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Cao, P., Liang, G., Gao, X. et al. Three new nor-dammarane triterpenoids from Dysoxylum hainanense with particular cytotoxicity against glioma cell line. Arch. Pharm. Res. 36, 322–326 (2013). https://doi.org/10.1007/s12272-013-0030-9

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  • DOI: https://doi.org/10.1007/s12272-013-0030-9

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