Archives of Pharmacal Research

, Volume 33, Issue 8, pp 1135–1141

Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01

  • Santi Thohinung
  • Somdej Kanokmedhakul
  • Kwanjai Kanokmedhakul
  • Veerapol Kukongviriyapan
  • Ornanong Tusskorn
  • Kasem Soytong
Research Articles Drug Discovery and Development

DOI: 10.1007/s12272-010-0801-5

Cite this article as:
Thohinung, S., Kanokmedhakul, S., Kanokmedhakul, K. et al. Arch. Pharm. Res. (2010) 33: 1135. doi:10.1007/s12272-010-0801-5

Abstract

Nine 10-(indol-3-yl)-[13]cytochalasans such as a new chaetoglobosin V (1); two new natural products, prochaetoglobosin III (2) and prochaetoglobosin IIIed (3); six known chaetoglobosins B-D (4–6), F (7), and G (8) and isochaetoglobosin D (9) in addition to two known sterols, 24(R)-5α,8α-epidioxyergosta-6–22-diene-3β-ol (10) and ergosterol (11), were isolated from the fungus Chaetomium elatum ChE01. The structures of these compounds were elucidated by spectroscopic methods. Compounds 1–9 showed cytotoxicity against the human breast cancer (IC50 2.54–21.29 μM) and cholangiocarcinoma cell lines (IC50 3.41–86.95 μM).

Key words

ChaetomiumChaetomium elatumChaetoglobosinCytotoxicityCholangiocarcinoma

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  • Santi Thohinung
    • 1
  • Somdej Kanokmedhakul
    • 1
  • Kwanjai Kanokmedhakul
    • 1
  • Veerapol Kukongviriyapan
    • 2
  • Ornanong Tusskorn
    • 2
  • Kasem Soytong
    • 3
  1. 1.Natural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of ScienceKhon Kaen UniversityKhon KaenThailand
  2. 2.Department of Pharmacology, Faculty of MedicineKhon Kaen UniversityKhon KaenThailand
  3. 3.Plant Pest Management, Faculty of Agricultural TechnologyKing Mongkut’s Institute of Technology LadkrabangLadkrabang, BangkokThailand