Research Articles Drug Discovery and Development

Archives of Pharmacal Research

, Volume 33, Issue 8, pp 1135-1141

Cytotoxic 10-(indol-3-yl)-[13]cytochalasans from the fungus Chaetomium elatum ChE01

  • Santi ThohinungAffiliated withNatural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University
  • , Somdej KanokmedhakulAffiliated withNatural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University Email author 
  • , Kwanjai KanokmedhakulAffiliated withNatural Products Research Unit, Department of Chemistry and Center for Innovation in Chemistry, Faculty of Science, Khon Kaen University
  • , Veerapol KukongviriyapanAffiliated withDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University
  • , Ornanong TusskornAffiliated withDepartment of Pharmacology, Faculty of Medicine, Khon Kaen University
  • , Kasem SoytongAffiliated withPlant Pest Management, Faculty of Agricultural Technology, King Mongkut’s Institute of Technology Ladkrabang

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Abstract

Nine 10-(indol-3-yl)-[13]cytochalasans such as a new chaetoglobosin V (1); two new natural products, prochaetoglobosin III (2) and prochaetoglobosin IIIed (3); six known chaetoglobosins B-D (4–6), F (7), and G (8) and isochaetoglobosin D (9) in addition to two known sterols, 24(R)-5α,8α-epidioxyergosta-6–22-diene-3β-ol (10) and ergosterol (11), were isolated from the fungus Chaetomium elatum ChE01. The structures of these compounds were elucidated by spectroscopic methods. Compounds 1–9 showed cytotoxicity against the human breast cancer (IC50 2.54–21.29 μM) and cholangiocarcinoma cell lines (IC50 3.41–86.95 μM).

Key words

Chaetomium Chaetomium elatum Chaetoglobosin Cytotoxicity Cholangiocarcinoma