Archives of Pharmacal Research

, Volume 33, Issue 6, pp 831–842

Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings

Research Articles Drug Design

DOI: 10.1007/s12272-010-0605-7

Cite this article as:
Zhang, D., Jia, J., Meng, L. et al. Arch. Pharm. Res. (2010) 33: 831. doi:10.1007/s12272-010-0605-7

Abstract

Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcusaureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.

Key words

2-Butyl succinate-based hydroxamate derivativesIsoxazoleSynthesisAntibacterial activity

Copyright information

© The Pharmaceutical Society of Korea and Springer Netherlands 2010

Authors and Affiliations

  1. 1.School of Chemistry and Chemical EngineeringShandong UniversityJinan, ShandongChina
  2. 2.School of Chemical EngineeringShandong Institute of Light IndustryJinan, ShandongChina
  3. 3.Tianjin Key Laboratory of Molecular Design and Drug DiscoveryTianjin Institute of Pharmaceutical ResearchTianjinChina
  4. 4.School of Chemistry and Chemical EngineeringShandong UniversityJinan City, Shandong ProvinceChina
  5. 5.School of Chemical Engineering, Shandong Institute of Light IndustryWestern University Science ParkJinan City, Shandong ProvinceChina