Research Articles Drug Design

Archives of Pharmacal Research

, Volume 33, Issue 6, pp 831-842

Synthesis and preliminary antibacterial evaluation of 2-butyl succinate-based hydroxamate derivatives containing isoxazole rings

  • Datong ZhangAffiliated withSchool of Chemistry and Chemical Engineering, Shandong UniversitySchool of Chemical Engineering, Shandong Institute of Light Industry Email author 
  • , Jiong JiaAffiliated withSchool of Chemistry and Chemical Engineering, Shandong University
  • , Lijuan MengAffiliated withSchool of Chemistry and Chemical Engineering, Shandong University
  • , Weiren XuAffiliated withTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research
  • , Lida TangAffiliated withTianjin Key Laboratory of Molecular Design and Drug Discovery, Tianjin Institute of Pharmaceutical Research
  • , Jianwu WangAffiliated withSchool of Chemistry and Chemical Engineering, Shandong University Email author 

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Abstract

Two series of novel 2-butyl succinate-based Hydroxamate derivatives containing isoxazole rings were synthesized, characterized and evaluated for antibacterial activity. The synthesized compounds were found to exhibit weak to moderate inhibitory activity against Staphytlococcus aureu and Klebsiellar pneumonia in vitro. All the compounds synthesized were found to be more effective against Klebsiellar pneumonia compared to Staphytlococcus aureu.

Key words

2-Butyl succinate-based hydroxamate derivatives Isoxazole Synthesis Antibacterial activity