Research Articles Drug Actions

Archives of Pharmacal Research

, Volume 32, Issue 9, pp 1309-1315

Cell growth inhibition and gene expression regulation by (-)-epigallocatechin-3-gallate in human cervical cancer cells

  • Yanyan QiaoAffiliated withDepartment of Reproductive Medicine, Basic Medical College, Capital Medical University
  • , Jinyan CaoAffiliated withDepartment of Zoology, North Carolina State University
  • , Liangqun XieAffiliated withDepartment of Reproductive Medicine, Basic Medical College, Capital Medical University
  • , Xiaolin ShiAffiliated withDepartment of Reproductive Medicine, Basic Medical College, Capital Medical University Email author 

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Abstract

EGCG [(-)-epigallocatechin-3-gallate] has shown its antitumor ability and perhaps a potential regimen for cancer patients. The goal of this study was to investigate the effect of EGCG on human papilloma virus (HPV) positive cervical cancer cell lines. EGCG inhibited the growth of CaSki (HPV16 positive) and HeLa (HPV18 positive) cells in a time- and concentration-dependent manner. Cell cycle arrest and apoptosis were observed in two cell lines after EGCG exposure. More importantly, we focused on EGCG regulation ability on pivotal genes involved in cervical cancer: viral oncogenes E6/E7, estrogen receptor (ER) and aromatase. Our results suggested that EGCG may be suitable for prevention and treatment of cervical cancer.

Key words

EGCG Cervical cancer HPV ER Aromatase