Archives of Pharmacal Research

, Volume 31, Issue 5, pp 666–670

A new pancreatic lipase inhibitor isolated from the roots of Actinidia arguta

  • Dae Sik Jang
  • Ga Young Lee
  • Junghyun Kim
  • Yun Mi Lee
  • Jong Min Kim
  • Young Sook Kim
  • Jin Sook Kim
Articles Drug Efficacy and Safety

DOI: 10.1007/s12272-001-1210-9

Cite this article as:
Jang, D.S., Lee, G.Y., Kim, J. et al. Arch. Pharm. Res. (2008) 31: 666. doi:10.1007/s12272-001-1210-9

Abstract

A new coumaroyl triterpene, 3-O-trans-p-coumaroyl actinidic acid (1), as well as five known triterpenes, ursolic acid (2), 23-hydroxyursolic acid (3), corosolic acid (4), asiatic acid (5) and betulinic acid (6) were isolated from an EtOAc-soluble extract of the roots of Actinidia arguta. The structure of compound 1 was elucidated from interpretation of the spectroscopic data, particularly by extensive 1D and 2D NMR studies. All the isolates (1–6) were evaluated in vitro for their inhibitory activities on pancreatic lipase (PL). Of the isolates, the new compound 1 possessed the highest inhibitory activity on PL, with an IC50 of 14.95 μM, followed by ursolic acid (2, IC50 = 15.83 μM). The other four triterpenes (3–6) also showed significant PL inhibitory activity, with IC50 values ranging from 20.42 to 76.45 μM.

Key words

Actinidia arguta Actinidiaceae 3-O-trans-p-Coumaroyl actinidic acid Triterpene Pancreatic lipase Obesity 

Copyright information

© The Pharmaceutical Society of Korea 2008

Authors and Affiliations

  • Dae Sik Jang
    • 1
  • Ga Young Lee
    • 1
  • Junghyun Kim
    • 1
  • Yun Mi Lee
    • 1
  • Jong Min Kim
    • 1
  • Young Sook Kim
    • 1
  • Jin Sook Kim
    • 1
  1. 1.Department of Herbal Pharmaceutical DevelopmentKorea Institute of Oriental MedicineDaejeonKorea

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