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Taspase1 — Lizenz zum Schneiden

Protease-Forschung

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Abstract

Proteases not only play an essential role in biological processes, they serve as clinically approved targets of current oncological approaches. As such, Taspase1 was postulated as therapeutic target in leukemogenesis. However, our molecular knowledge on its function is still rather fragmentary as still no effective inhibitors are available. Moreover the Taspase1 degradome, the collectivity of its target proteins, could be revealed just recently by the development of special cell-based assays.

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Literatur

  1. Turk B (2006) Targeting proteases: successes, failures and future prospects. Nat Rev Drug Discov 5:785–799

    Article  PubMed  CAS  Google Scholar 

  2. Hsieh JJ, Cheng EH, Korsmeyer SJ (2003) Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell 115:293–303

    Article  PubMed  CAS  Google Scholar 

  3. Zhou H, Spicuglia S, Hsieh JJ et al. (2006) Uncleaved TFIIA is a substrate for taspase 1 and active in transcription. Mol Cell Biol 26:2728–2735

    Article  PubMed  CAS  Google Scholar 

  4. Bier C, Knauer SK, Klapthor A et al. (2011) Cell-based analysis of structure-function activity of threonine aspartase 1. J Biol Chem 286:3007–3017

    Article  PubMed  CAS  Google Scholar 

  5. Knauer SK, Fetz V, Rabenstein J et al. (2011) Bioassays to monitor Taspase1 function for the identification of pharmacogenetic inhibitors. PLoS One 6:e18253

    Article  PubMed  CAS  Google Scholar 

  6. Bier C, Knauer SK, Docter D et al. (2011) The importin-alpha/nucleophosmin switch controls taspase1 protease function. Traffic 12:703–714

    Article  PubMed  CAS  Google Scholar 

  7. Bier C, Hecht R, Kunst L et al. (2012) Overexpression of the catalytically impaired Taspase1 T234V or Taspase1 D233A variants does not have a dominant negative effect in T(4;11) leukemia cells. PLoS One 7:e34142

    Article  PubMed  CAS  Google Scholar 

  8. Bier C, Knauer SK, Wunsch D et al. (2012) Allosteric inhibition of Taspase1’s pathobiological activity by enforced dimerization in vivo. FASEB J 26:3421–3429

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Mainz Screening Center, Universitätsmedizin Mainz, Mainz, Germany

    Roland H. Stauber

  2. Zentrum für Medizinische Biotechnologie, Universität Duisburg-Esssen, Esssen, Germany

    Shirley K. Knauer

  3. Molekulare und Zelluläre Onkologie Mainz Screening Center, Universitätsmedizin Mainz, Langenbeckstraße 1, D-55131, Mainz, Germany

    Roland H. Stauber

  4. Molekularmedizin II Zentrum für Medizinische Biotechnologie, Universität Duisburg-Essen, Universitätsstraße 5, D-45141, Essen, Germany

    Shirley K. Knauer

Authors
  1. Roland H. Stauber
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  2. Shirley K. Knauer
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Corresponding authors

Correspondence to Roland H. Stauber or Shirley K. Knauer.

Additional information

Roland H. Stauber Jahrgang 1963. 1983–1989 Biologiestudium an der Universität Würzburg. 1989–1994 Promotion an der Universität Würzburg. 1994–1997 Postdoktorand am National Cancer Institute in Bethesda, MD, USA. 1997–2001 Gruppenleiter am Institut für Virologie der Universität Erlangen. 1999 Habilitation. 2001–2006 Gruppenleiter am Georg-Speyer-Haus in Frankfurt a. M. Seit 2006 Professor an der Universitätsmedizin Mainz.

Shirley K. Knauer Jahrgang 1976. 1995–2000 Biologiestudium an der Universität Erlangen. 2005 Promotion an der Universität Frankfurt a. M. 2005–2006 Postdoktorandin am Georg-Speyer-Haus in Frankfurt a. M. 2007–2009 Junior-Gruppenleiterin an der Universitätsmedizin Mainz. 2008 Habilitation. Seit 2010 Junior-Professorin am Zentrum für Medizinische Biotechnologie der Universität Duisburg-Essen.

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Stauber, R.H., Knauer, S.K. Taspase1 — Lizenz zum Schneiden. Biospektrum 19, 134–136 (2013). https://doi.org/10.1007/s12268-013-0281-5

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  • DOI: https://doi.org/10.1007/s12268-013-0281-5

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