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Endothelial Dysfunction and Cardiac Allograft Vasculopathy

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Abstract

Cardiac allograft vasculopathy remains a major challenge to long-term survival after heart transplantation. Endothelial injury and dysfunction, as a result of multifactorial immunologic and nonimmunologic insults in the donor and the recipient, are prevalent early after transplant and may be precursors to overt cardiac allograft vasculopathy. Current strategies for managing cardiac allograft vasculopathy, however, rely on the identification and treatment of established disease. Improved understanding of mechanisms leading to endothelial dysfunction in heart transplant recipients may provide the foundation for the development of sensitive screening techniques and preventive therapies.

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Abbreviations

ACE-I:

Angiotensin converting enzyme inhibitor

ARB:

Angiotensin receptor blocker

cGMP:

Cyclic guanosine monophosphate

eNOS:

Endothelial nitric oxide synthase

GTP:

Guanosine triphosphate

iNOS:

Inducible nitric oxide synthase

NO:

Nitric oxide

PDE-5:

Phosphodiesterase type 5

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Acknowledgments

Special thanks are due to Roderick Adams, MD and Anne Marie Weber-Main, PhD, who critically reviewed and edited article drafts.

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Authors and Affiliations

  1. Cardiovascular Division, University of Minnesota, Minneapolis, MN, USA

    Monica Colvin-Adams, Nonyelum Harcourt & Daniel Duprez

  2. Cardiovascular Division, Advanced Heart Failure and Transplantation Section, University of Minnesota, 401 East River Road MMC 508, Minneapolis, MN, 55455, USA

    Monica Colvin-Adams

  3. Lillehei Clinical Research Unit, Cardiovascular Division, University of Minnesota, 401 East River Road MMC 508, Minneapolis, MN, 55455, USA

    Nonyelum Harcourt

  4. Cardiovascular Division, Section on Prevention, University of Minnesota, 401 East River Road MMC 508, Minneapolis, MN, 55455, USA

    Daniel Duprez

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Correspondence to Monica Colvin-Adams.

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Colvin-Adams, M., Harcourt, N. & Duprez, D. Endothelial Dysfunction and Cardiac Allograft Vasculopathy. J. of Cardiovasc. Trans. Res. 6, 263–277 (2013). https://doi.org/10.1007/s12265-012-9414-3

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