Neuroscience Bulletin

, Volume 30, Issue 4, pp 667–670

Non-apoptotic role of caspase-3 in synapse refinement


DOI: 10.1007/s12264-014-1454-4

Cite this article as:
Wang, JY. & Luo, ZG. Neurosci. Bull. (2014) 30: 667. doi:10.1007/s12264-014-1454-4


Caspases, a family of cysteine proteases, mediate programmed cell death during early neural development and neurodegeneration, as well as following neurotoxic insults. Notably, accumulating lines of evidence have shown non-apoptotic roles of caspases in the structural and functional plasticity of neuronal circuits under physiological conditions, such as growth-cone dynamics and axonal/dendritic pruning, as well as neuronal excitability and plasticity. Here, we summarize recent progress on the roles of caspases in synaptic refinement.


caspasesneuronal plasticitysynaptic refinement

Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological SciencesChinese Academy of SciencesShanghaiChina