Non-apoptotic role of caspase-3 in synapse refinement
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- Wang, J. & Luo, Z. Neurosci. Bull. (2014) 30: 667. doi:10.1007/s12264-014-1454-4
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Caspases, a family of cysteine proteases, mediate programmed cell death during early neural development and neurodegeneration, as well as following neurotoxic insults. Notably, accumulating lines of evidence have shown non-apoptotic roles of caspases in the structural and functional plasticity of neuronal circuits under physiological conditions, such as growth-cone dynamics and axonal/dendritic pruning, as well as neuronal excitability and plasticity. Here, we summarize recent progress on the roles of caspases in synaptic refinement.