Review

Neuroscience Bulletin

, Volume 30, Issue 4, pp 601-609

MeCP2: multifaceted roles in gene regulation and neural development

  • Tian-Lin ChengAffiliated withInstitute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Email author 
  • , Zilong QiuAffiliated withInstitute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences

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Abstract

Methyl-CpG-binding protein 2 (MeCP2) is a classic methylated-DNA-binding protein, dysfunctions of which lead to various neurodevelopmental disorders such as Rett syndrome and autism spectrum disorder. Initially recognized as a transcriptional repressor, MeCP2 has been studied extensively and its functions have been expanded dramatically in the past two decades. Recently, it was found to be involved in gene regulation at the post-transcriptional level. MeCP2 represses nuclear microRNA processing by interacting directly with the Drosha/DGCR8 complex. In addition to its multifaceted functions, MeCP2 is remarkably modulated by posttranslational modifications such as phosphorylation, SUMOylation, and acetylation, providing more regulatory dimensions to its functions. The role of MeCP2 in the central nervous system has been studied extensively, from neurons to glia. Future investigations combining molecular, cellular, and physiological methods are necessary for defining the roles of MeCP2 in the brain and developing efficient treatments for MeCP2-related brain disorders.

Keywords

MeCP2 Rett syndrome central nervous system gene expression regulation post-translational modification post-transcriptional regulation glia