Neuroscience Bulletin

, Volume 29, Issue 6, pp 773–778

Role of the PTEN signaling pathway in autism spectrum disorder

  • Jing-Wen Lv
  • Tian-Lin Cheng
  • Zi-Long Qiu
  • Wen-Hao Zhou
Review

DOI: 10.1007/s12264-013-1382-3

Cite this article as:
Lv, JW., Cheng, TL., Qiu, ZL. et al. Neurosci. Bull. (2013) 29: 773. doi:10.1007/s12264-013-1382-3

Abstract

Autism is an etiologically heterogeneous group of neurodevelopmental disorders, diagnosed mostly by the clinical behavioral phenotypes. The concept that the tumor-related gene PTEN plays a critical role in autism spectrum disorder has emerged over the last decade. In this review, we focus on the essential role of the PTEN signaling pathway in neuronal differentiation and the formation of neural circuitry, as well as genetic mouse models with Pten manipulations. Particularly, accumulated data suggest that the effect of PTEN on neural stem-cell development contributes significantly to the pathophysiology of autism spectrum disorders.

Keywords

PTEN TSC1/2 autism synapse neural stem cells 

Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Jing-Wen Lv
    • 1
  • Tian-Lin Cheng
    • 2
  • Zi-Long Qiu
    • 2
  • Wen-Hao Zhou
    • 1
  1. 1.Department of NeonatologyChildren’s Hospital of Fudan UniversityShanghaiChina
  2. 2.Institute of Neuroscience, Shanghai Institute of Biological SciencesChinese Academy of SciencesShanghaiChina