Review

Neuroscience Bulletin

, Volume 29, Issue 4, pp 436-444

Animal models of axon regeneration after spinal cord injury

  • Do-Hun LeeAffiliated withMiami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine
  • , Jae K. LeeAffiliated withMiami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine Email author 

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Abstract

With advances in genetic and imaging techniques, investigating axon regeneration after spinal cord injury in vivo is becoming more common in the literature. However, there are many issues to consider when using animal models of axon regeneration, including species, strains and injury models. No single particular model suits all types of experiments and each hypothesis being tested requires careful selection of the appropriate animal model. in this review, we describe several commonly-used animal models of axon regeneration in the spinal cord and discuss their advantages and disadvantages.

Keywords

pyramidotomy strain differences contusion injury models