Review

Neuroscience Bulletin

, Volume 29, Issue 4, pp 467-476

Anatomical and electrophysiological plasticity of locomotor networks following spinal transection in the salamander

  • Jean-Marie CabelguenAffiliated withNeurocentre Magendie, INSERM U 862 — Bordeaux University Email author 
  • , Stéphanie ChevallierAffiliated withNeurocentre Magendie, INSERM U 862 — Bordeaux University
  • , Ianina Amontieva-PotapovaAffiliated withNeurocentre Magendie, INSERM U 862 — Bordeaux University
  • , Céline PhilippeAffiliated withNeurocentre Magendie, INSERM U 862 — Bordeaux University

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Abstract

Recovery of locomotor behavior following spinal cord injury can occur spontaneously in some vertebrates, such as fish, urodele amphibians, and certain reptiles. This review provides an overview of the current status of our knowledge on the anatomical and electrophysiological changes occurring within the spinal cord that lead to, or are associated with the re-expression of locomotion in spinally-transected salamanders. A better understanding of these processes will help to devise strategies for restoring locomotor function in mammals, including humans.

Keywords

salamander spinal cord locomotor recovery regeneration