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Signaling pathways that regulate axon regeneration

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Abstract

Neurons in the mammalian central nervous system (CNS) cannot regenerate axons after injury. in contrast, neurons in the mammalian peripheral nervous system and in some non-mammalian models, such as C. elegans and Drosophila, are able to regrow axons. Understanding the molecular mechanisms by which these neurons support axon regeneration will help us find ways to enhance mammalian CNS axon regeneration. Here, recent studies in which signaling pathways regulating naturally-occurring axon regeneration that have been identified are reviewed, focusing on how these pathways control gene expression and growth-cone function during axon regeneration.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery, The Johns Hopkins University, Baltimore, Maryland, USA

    Saijilafu, Bo-Yin Zhang & Feng-Quan Zhou

  2. The Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University, Baltimore, Maryland, USA

    Feng-Quan Zhou

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  1. Saijilafu
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Correspondence to Feng-Quan Zhou.

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Saijilafu, Zhang, BY. & Zhou, FQ. Signaling pathways that regulate axon regeneration. Neurosci. Bull. 29, 411–420 (2013). https://doi.org/10.1007/s12264-013-1357-4

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