Review

Neuroscience Bulletin

, Volume 29, Issue 4, pp 411-420

Signaling pathways that regulate axon regeneration

  • SaijilafuAffiliated withDepartment of Orthopaedic Surgery, The Johns Hopkins University
  • , Bo-Yin ZhangAffiliated withDepartment of Orthopaedic Surgery, The Johns Hopkins University
  • , Feng-Quan ZhouAffiliated withDepartment of Orthopaedic Surgery, The Johns Hopkins UniversityThe Solomon H. Snyder Department of Neuroscience, The Johns Hopkins University Email author 

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Abstract

Neurons in the mammalian central nervous system (CNS) cannot regenerate axons after injury. in contrast, neurons in the mammalian peripheral nervous system and in some non-mammalian models, such as C. elegans and Drosophila, are able to regrow axons. Understanding the molecular mechanisms by which these neurons support axon regeneration will help us find ways to enhance mammalian CNS axon regeneration. Here, recent studies in which signaling pathways regulating naturally-occurring axon regeneration that have been identified are reviewed, focusing on how these pathways control gene expression and growth-cone function during axon regeneration.

Keywords

axon regeneration axonal growth signal transduction