Neuroscience Bulletin

, Volume 29, Issue 2, pp 165–176

Polydendrocytes in development and myelin repair

Authors

  • Hao Zuo
    • Department of Physiology and NeurobiologyUniversity of Connecticut
    • Department of Physiology and NeurobiologyUniversity of Connecticut
    • University of Connecticut Stem Cell Institute
Review

DOI: 10.1007/s12264-013-1320-4

Cite this article as:
Zuo, H. & Nishiyama, A. Neurosci. Bull. (2013) 29: 165. doi:10.1007/s12264-013-1320-4

Abstract

Polydendrocytes (NG2 cells) are a distinct type of glia that populate the developing and adult central nervous systems (CNS). In the adult CNS, they retain mitotic activity and represent the largest proliferating cell population. Genetic and epigenetic mechanisms regulate the fate of polydendrocytes, which give rise to both oligodendrocytes and astrocytes. In addition, polydendrocytes actively differentiate into myelin-forming oligodendrocytes in response to demyelination. This review summarizes the current knowledge regarding polydendrocyte development, which provides an important basis for understanding the mechanisms that lead to the remyelination of demyelinated lesions.

Keywords

polydendrocytesNG2 cellsoligodendrocytesmyelincell fate
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Copyright information

© Shanghai Institutes for Biological Sciences, CAS and Springer-Verlag Berlin Heidelberg 2013