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Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats

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Abstract

Progesterone is an efficient candidate for treating stroke and traumatic brain damage. The current study was designed to investigate the effects of progesterone on glucose transporter proteins (GLUT1 and GLUT3) during hypoxic-ischemic injury in a neonatal rat model. We demonstrated strong staining for GLUT1 in the walls of blood vessels and GLUT3 immunoreactivity in hippocampal neurons after hypoxiaischemia. Hypoxia-ischemia elevated GLUT1 and GLUT3 at both the mRNA and protein levels in the hippocampus, and pre-treatment with progesterone (8 mg/kg) further enhanced their accumulation until 24 h after hypoxic-ischemic injury. These results showed that progesterone treatment induced the accumulation of both GLUT1 and GLUT3 transporters, and an energy-compensation mechanism may be involved in the neuroprotective effect of progesterone during hypoxic-ischemic injury after cerebral ischemic attacks.

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Authors and Affiliations

  1. Department of Physiology and Neurobiology, Xinxiang Medical University, Xinxiang, 453003, China

    Xinjuan Li, Hua Han, Ruanling Hou, Linyu Wei, Guohong Wang, Chaokun Li & Dongliang Li

  2. Henan Key Lab of Biological Psychiatry, Xinxiang, 453002, China

    Dongliang Li

  3. Department of Ultrasonic Diagnosis, Central Hospital of Xinxiang City, Xinxiang, 453000, China

    Hua Han

Authors
  1. Xinjuan Li
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  2. Hua Han
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  3. Ruanling Hou
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  4. Linyu Wei
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  5. Guohong Wang
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  6. Chaokun Li
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  7. Dongliang Li
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Correspondence to Chaokun Li or Dongliang Li.

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Li, X., Han, H., Hou, R. et al. Progesterone treatment before experimental hypoxia-ischemia enhances the expression of glucose transporter proteins GLUT1 and GLUT3 in neonatal rats. Neurosci. Bull. 29, 287–294 (2013). https://doi.org/10.1007/s12264-013-1298-y

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  • DOI: https://doi.org/10.1007/s12264-013-1298-y

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