Genes & Nutrition

, 10:450

Design and baseline characteristics of the Food4Me study: a web-based randomised controlled trial of personalised nutrition in seven European countries

  • Carlos Celis-Morales
  • Katherine M. Livingstone
  • Cyril F. M. Marsaux
  • Hannah Forster
  • Clare B. O’Donovan
  • Clara Woolhead
  • Anna L. Macready
  • Rosalind Fallaize
  • Santiago Navas-Carretero
  • Rodrigo San-Cristobal
  • Silvia Kolossa
  • Kai Hartwig
  • Lydia Tsirigoti
  • Christina P. Lambrinou
  • George Moschonis
  • Magdalena Godlewska
  • Agnieszka Surwiłło
  • Keith Grimaldi
  • Jildau Bouwman
  • E. J. Daly
  • Victor Akujobi
  • Rick O’Riordan
  • Jettie Hoonhout
  • Arjan Claassen
  • Ulrich Hoeller
  • Thomas E. Gundersen
  • Siv E. Kaland
  • John N. S. Matthews
  • Yannis Manios
  • Iwona Traczyk
  • Christian A. Drevon
  • Eileen R. Gibney
  • Lorraine Brennan
  • Marianne C. Walsh
  • Julie A. Lovegrove
  • J. Alfredo Martinez
  • Wim H. M. Saris
  • Hannelore Daniel
  • Mike Gibney
  • John C. Mathers
Research Paper

DOI: 10.1007/s12263-014-0450-2

Cite this article as:
Celis-Morales, C., Livingstone, K.M., Marsaux, C.F.M. et al. Genes Nutr (2015) 10: 450. doi:10.1007/s12263-014-0450-2

Abstract

Improving lifestyle behaviours has considerable potential for reducing the global burden of non-communicable diseases, promoting better health across the life-course and increasing well-being. However, realising this potential will require the development, testing and implementation of much more effective behaviour change interventions than are used conventionally. Therefore, the aim of this study was to conduct a multi-centre, web-based, proof-of-principle study of personalised nutrition (PN) to determine whether providing more personalised dietary advice leads to greater improvements in eating patterns and health outcomes compared to conventional population-based advice. A total of 5,562 volunteers were screened across seven European countries; the first 1,607 participants who fulfilled the inclusion criteria were recruited into the trial. Participants were randomly assigned to one of the following intervention groups for a 6-month period: Level 0—control group—receiving conventional, non-PN advice; Level 1—receiving PN advice based on dietary intake data alone; Level 2—receiving PN advice based on dietary intake and phenotypic data; and Level 3—receiving PN advice based on dietary intake, phenotypic and genotypic data. A total of 1,607 participants had a mean age of 39.8 years (ranging from 18 to 79 years). Of these participants, 60.9 % were women and 96.7 % were from white-European background. The mean BMI for all randomised participants was 25.5 kg m−2, and 44.8 % of the participants had a BMI ≥ 25.0 kg m−2. Food4Me is the first large multi-centre RCT of web-based PN. The main outcomes from the Food4Me study will be submitted for publication during 2015.

Keywords

Personalised nutrition Web-based Phenotype Genotype Randomised controlled trial 

Supplementary material

12263_2014_450_MOESM1_ESM.docx (1.1 mb)
Data Sharing: The following data (advice leaflet, example of participant’s report and cut-off points for each of the nutritional and phenotypic variables used to derive personalised goals and advice) are available in Supplementary Material. Requests for additional information should be directed to the corresponding author (Professor John Mathers, john.mathers@newcastle.ac.uk). (DOCX 1168 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  • Carlos Celis-Morales
    • 1
  • Katherine M. Livingstone
    • 1
  • Cyril F. M. Marsaux
    • 2
  • Hannah Forster
    • 3
  • Clare B. O’Donovan
    • 3
  • Clara Woolhead
    • 3
  • Anna L. Macready
    • 4
  • Rosalind Fallaize
    • 4
  • Santiago Navas-Carretero
    • 5
    • 6
  • Rodrigo San-Cristobal
    • 5
  • Silvia Kolossa
    • 7
  • Kai Hartwig
    • 7
  • Lydia Tsirigoti
    • 8
  • Christina P. Lambrinou
    • 8
  • George Moschonis
    • 8
  • Magdalena Godlewska
    • 9
  • Agnieszka Surwiłło
    • 9
  • Keith Grimaldi
    • 10
  • Jildau Bouwman
    • 11
  • E. J. Daly
    • 12
  • Victor Akujobi
    • 12
  • Rick O’Riordan
    • 12
  • Jettie Hoonhout
    • 13
  • Arjan Claassen
    • 14
  • Ulrich Hoeller
    • 15
  • Thomas E. Gundersen
    • 16
  • Siv E. Kaland
    • 16
  • John N. S. Matthews
    • 17
  • Yannis Manios
    • 8
  • Iwona Traczyk
    • 9
  • Christian A. Drevon
    • 18
  • Eileen R. Gibney
    • 3
  • Lorraine Brennan
    • 3
  • Marianne C. Walsh
    • 3
  • Julie A. Lovegrove
    • 4
  • J. Alfredo Martinez
    • 5
    • 6
  • Wim H. M. Saris
    • 3
  • Hannelore Daniel
    • 7
  • Mike Gibney
    • 3
  • John C. Mathers
    • 1
  1. 1.Human Nutrition Research Centre, Institute of Cellular MedicineNewcastle UniversityNewcastle upon TyneUK
  2. 2.Department of Human Biology, NUTRIM School for Nutrition, Toxicology and MetabolismMaastricht University Medical CentreMaastrichtThe Netherlands
  3. 3.UCD Institute of Food and HealthUniversity College DublinDublin 4Republic of Ireland
  4. 4.Hugh Sinclair Unit of Human Nutrition and Institute for Cardiovascular and Metabolic ResearchUniversity of ReadingReadingUK
  5. 5.Department of Nutrition, Food Science and PhysiologyUniversity of NavarraPamplonaSpain
  6. 6.CIBER Fisiopatología Obesidad y Nutrición (CIBERobn)Instituto de Salud Carlos IIIMadridSpain
  7. 7.Biochemistry Unit, ZIEL Research Center of Nutrition and Food SciencesTechnische Universität MünchenMunichGermany
  8. 8.Department of Nutrition and DieteticsHarokopio UniversityAthensGreece
  9. 9.National Food and Nutrition Institute (IZZ)WarsawPoland
  10. 10.Eurogenetica LtdBurnham-on-SeaUK
  11. 11.Microbiology and Systems Biology GroupTNOZeistThe Netherlands
  12. 12.Crème GlobalTrinity Technology and Enterprise CampusDublin 2Ireland
  13. 13.Experiences Research DepartmentPhilips ResearchEindhovenThe Netherlands
  14. 14.Software Products and SystemsPGI, Philips Innovation ServicesEindhovenThe Netherlands
  15. 15.DSM Nutritional ProductsAnalytical Research CentreBaselSwitzerland
  16. 16.Vitas ASOsloNorway
  17. 17.School of Mathematics and StatisticsNewcastle UniversityNewcastleUK
  18. 18.Department of Nutrition, Institute of Basic Medical Sciences, Faculty of MedicineUniversity of OsloOsloNorway

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