Genes & Nutrition

, Volume 8, Issue 6, pp 561–569

Vitamin D receptor BsmI polymorphism modulates soy intake and 25-hydroxyvitamin D supplementation benefits in cardiovascular disease risk factors profile

  • Jose C. E. Serrano
  • David De Lorenzo
  • Anna Cassanye
  • Meritxell Martín-Gari
  • Alberto Espinel
  • Marco Antonio Delgado
  • Reinald Pamplona
  • Manuel Portero-Otin
Research Paper

DOI: 10.1007/s12263-013-0356-4

Cite this article as:
Serrano, J.C.E., De Lorenzo, D., Cassanye, A. et al. Genes Nutr (2013) 8: 561. doi:10.1007/s12263-013-0356-4

Abstract

Vitamin D receptor polymorphisms may predispose that not all individuals could have benefits from the nutritional supplementation of 25-hydroxyvitamin D. Furthermore, vitamin D-related cardiovascular effects may also be influenced by soy isoflavones considered endocrine regulators of cardiovascular homeostasis. To find possible gene–diet interactions by evaluating individualized lipid metabolism benefits from an increase in soy and 25-hydroxyvitamin D intake, 106 healthy individuals, genotyped for vitamin D receptor (VDR) gene polymorphism rs1544410 (BsmI) were randomly assigned to either no intake, to daily 250 mL or 500 mL of a 25-hydroxyvitamin D supplemented SB for 2 months. The soybean beverage induced differences in cardiovascular risk factors (lipid profile, blood pressure, TNFα and MCP-1), as well as vitamin D metabolites in a dose-gene-dependent relation. Thus, VDR BsmI polymorphism affected individual response being the GG genotype the ones that showed dose-dependent manner responsiveness in the reduction in total cholesterol, LDL and triglycerides in comparison with the AA/AG genotype. These differences were associated with increased plasma levels of 1α,25-dyhydroxyvitamin D3 in the carriers of the GG genotype. It was concluded that metabolic response to 25-hydroxyvitamin D and soybean supplementation is dependent on VDR BsmI GG genotype due to a higher conversion rate from vitamin D precursors.

Keywords

Vitamin D receptorVitamin DSoyLipid profile

Supplementary material

12263_2013_356_MOESM1_ESM.doc (45 kb)
Supplementary material 1 (DOC 45 kb)

Copyright information

© Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  • Jose C. E. Serrano
    • 1
  • David De Lorenzo
    • 1
  • Anna Cassanye
    • 1
  • Meritxell Martín-Gari
    • 1
  • Alberto Espinel
    • 2
  • Marco Antonio Delgado
    • 2
  • Reinald Pamplona
    • 1
  • Manuel Portero-Otin
    • 1
  1. 1.Department of Experimental Medicine, Faculty of MedicineUniversity of Lleida-IRBLleidaLleidaSpain
  2. 2.Instituto Tomás PascualMadridSpain