Abstract
Development of a primary cancer after treatment of the first with radiotherapy or chemotherapy is well documented, but it is common with hematological malignancies. Variety of reasons are suggested by various researchers, but a conclusive evidence is not yet available. Excepting a few correlations like the tamoxifen therapy and endometrial cancer, angiosarcoma of the breast following radiotherapy, occurrence of other metachronous malignancies seem to be dependent on genetic and environmental factors. A patient with three primary malignancies is presented here.
References
Reingold SR, Neugut AI, Meadows AT (2000) Second cancers; incidence, risk factors and management. In: Holland JF, Frei E, Pollock RE, Weichselbaum RR, Bast RC, Kufe DW (eds) Cancer Medicine, Hamilton, ON, Canada, pp 2399–2406
Cybulski C, Gorski B, Huzarski T et al (2004) CHEK2 is a multiorgan cancer susceptibility gene. Am J Hum Genet 75:1131–1135
Sadetzki S, Calderon-Margalit R, Peretz C et al (2002) Second primary breast cancer and thyroid disorders. Cancers Causes and Controls 14:367–375
Ronckers CM (2005) Thyroid cancer and multiple primary tumors in the SEER cancer registries. Int J Cancer 117:281–288
Rubino C, de Vathaire F, Dottorini ME et al (2003) Second primary malignancies in thyroid cancer patients. Br J Cancer 89:1638–1644
Verkooijen RBT, Smit JWA, Romijn JA et al (2006) The incidence of second primary tumors in thyroid cancer patients is increased, but not related to treatment of thyroid cancer. Eur J Endocrinol 155(6):801–806
Agrawal S, Eng C (2006) Differential expression of novel naturally occurring splice variants of PTEN and their functional consequences in Cowden syndrome and sporadic breast cancer. Hum Mol Genet 15:777–787
Bergman I, Beelen M, Gallee M et al (2000) The comprehensive cancer centres’ ALERT group. Risk and prognosis of endometrial cancer after tamoxifen for breast cancer. Lancet 356:881–887
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jayaraman, S., Balakrishnan, S. & Rao, D. Multiple Metachronous Malignancies, One Patient with Three Primary Malignancies. Indian J Surg 73, 377–379 (2011). https://doi.org/10.1007/s12262-011-0281-y
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12262-011-0281-y