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Processing and characterization of laser sintered hydroxyapatite scaffold for tissue engineering

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Abstract

The sintering processing of hydroxyapatite (HAP) powder was studied using selective laser sintering for bone tissue engineering. The effect of laser energy density on the microstructure, phase composition and mechanical properties of the sintered samples was investigated. The results indicate that the average grain size increases from 0.211 ± 0.039 to 0.979 ± 0.133 μm with increasing the laser energy density from 2.0 to 5.0 J/mm2. The maximum value of Vickers hardness and fracture toughness were 4.0 ± 0.13 Gpa and 1.28 ± 0.033 MPam1/2, respectively, when the laser energy density was 4.0 J/mm2. The XRD results indicated that the nano-HAP was decomposed into TCP with the laser energy density of above 4.0 J/mm2. In vitro bioactivity after soaking in simulated body fluid (SBF) for 3 ∼ 12 days showed that a bone-like apatite layer on the surface of the sintered samples. It indicated that the HAP scaffold possesses favorable mechanical properties and bioactivity, and may be used for bone tissue engineering.

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Authors and Affiliations

  1. State Key Laboratory of High Performance Complex Manufacturing, Central South University, Changsha, 410-083, China

    Cijun Shuai, Pei Feng & Chengde Cao

  2. Department of Regenerative Medicine & Cell Biology, Medical University of South Carolina, Charleston, SC, 29425, USA

    Cijun Shuai

  3. Cancer Research Institute, Central South University, Changsha, 410-078, China

    Shuping Peng

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  1. Cijun Shuai
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  2. Pei Feng
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Correspondence to Shuping Peng.

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Shuai, C., Feng, P., Cao, C. et al. Processing and characterization of laser sintered hydroxyapatite scaffold for tissue engineering. Biotechnol Bioproc E 18, 520–527 (2013). https://doi.org/10.1007/s12257-012-0508-1

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  • DOI: https://doi.org/10.1007/s12257-012-0508-1

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