Summary
Hematopoietic stem cell transplantation (HSCT) remains one of the most dynamic fields in hematology, as reflected by the large number of abstracts on new developments and establishing concepts in this scientific and clinical area, presented at the ASH meeting in December 2015. The role of haploidentical transplantation for recipients lacking an HLA-matched donor was further strengthened, and the use of an intelligently designed and carefully developed concept of immunomodulation, namely posttransplant cyclophosphamide, enabling successful transplantation across the multi-antigeneic HLA-barrier. Furthermore, with the development of novel antineoplastic therapies, both effective bridging to transplant, as well as prophylactic and preemptive interventions post HSCT will help increase the overall success of increasingly complex and individualized treatment concepts. Finally, novel cellular immunotherapies, most notably the genetically engineered chimeric antigen receptor (CAR) T cell concepts, will extend the therapeutic options for patients with hematological malignancies.
Similar content being viewed by others
References
Clausen J. ASH 2012: Allogeneic stem cell transplantation. Memo. 2013;6(3):174–6.
Gaballa S, et al. Results of a two-arm phase II clinical trial using post-transplantation cyclophosphamide for prevention of graft-versus-host disease in haploidentical and mismatched unrelated donors hematopoietic stem-cell transplantation. Blood. 2015;126:152.
Lee K‑H, et al. Allogeneic hematopoietic cell transplantation for acute myelogenous leukemia in remission – a prospective comparison of three different donor groups; matched sibling, matched unrelated, and haploidentical family donors. Blood. 2015;126:4379.
Wang Y, et al. Stem-cell transplantation in adults with Philadelphia-negative high-risk acute lymphoblastic leukemia in first complete remission: a prospective multicenter trial comparing haploidentical donors with identical sibling donors. Blood. 2015;126:62.
Lorentino F, et al. HLA disparities impact on outcomes after unmanipulated haploidentical hematopoietic stem cells transplantation (HaploSCT) in acute leukemia: a study from the acute leukemia working party of the European Group for Blood and Marrow Transplantation (EBMT). Blood. 2015;126:399.
Mussetti A, et al. Survival after T-cell replete haploidentical related donor transplant using post-transplant cyclophosphamide compared with matched unrelated donor (MUD) transplant for lymphoid malignancies. Blood. 2015;126:194.
Martinez C, et al. Alternative donors (umbilical cord blood and haploidentical donors) for allogeneic stem cell transplantation in relapsed/refractory hodgkin lymphoma: a retrospective analysis of the EBMT lymphoma working party and the spanish group of stem cell transplantation (GETH). Blood. 2015;126:4399.
Bertaina A, et al. Children with acute leukemia given hematopoietic stem cell transplantation (HSCT) from an HLA-compatible sibling, or an unrelated donor (UD) or an HLA-haploidentical relative after alpha/beta T-cell depletion have a comparable outcome. Blood. 2015;126:195.
Zhao Y‑L, et al. Improved Outcomes of Haploidentical Blood and Marrow Transplantation in Hematologic Malignancies: A Single Center Study of 514 Cases. Blood. 2015;126:3224.
Kasamon YL, et al. Nonmyeloablative (NMA), HLA-mismatched unrelated donor (mMUD) BMT with high-dose posttransplantation cyclophosphamide (PTCy) has outcomes similar to matched BMT. Blood. 2015;126:2002.
Schlenk R, et al. Midostaurin in combination with intensive induction and as single agent maintenance therapy after consolidation therapy with allogeneic hematopoietic stem cell transplantation or high-dose cytarabine (NCT01477606). Blood. 2015;126:322.
Brunner AM, et al. Hematopoietic cell transplantation with or without sorafenib maintenance for patients with FLT3-ITD acute myeloid leukemia in CR1. Blood. 2015;126:864.
Pratz KW, et al. Prospective study of peri-transplant use of sorafenib as remission maintenance for FLT3-ITD patients undergoing allogeneic transplantation. Blood. 2015;126:3164.
Bug G, et al. Phase I/II study of the deacetylase inhibitor panobinostat as maintenance therapy after an allogeneic stem cell transplantation in patients with high-risk MDS or AML: the panobest-trial. Blood. 2015;126:4344.
Luger S, et al. Tipifarnib as maintenance therapy in acute myeloid leukemia (AML) improves survival in a subgroup of patients with high risk disease. Results of the phase III intergroup trial E2902. Blood. 2015;126:1308.
Shipton MJ, et al. Seattle regimen RIC-HSCT in early-phase multiple myeloma: a multi-centre experience demonstrating very low treatment-related mortality and rapid graft-versus-myeloma effect associated with graft-versus-host disease. Blood. 2015;126:4355.
Schmid C, et al. Efficacy, safety and long term results of prophylactic and preemptive donor lymphocyte infusion after allogeneic stem cell transplantation for acute leukemia: a registry-based evaluation on 343 patients by the acute leukemia working party of EBMT. Blood. 2015;126:863.
Mehta RS, et al. Post-transplantation high dose cyclophosphamide as gvhd prophylaxis in 9/10 HLA-matched unrelated donors hematopoietic stem cell transplantation. Blood. 2015;126:3135.
Khoury HJ, et al. Outcomes of grades II–IV acute graft-versus-host disease post-allogeneic hematopoietic stem cell transplantation: how much progress was achieved? Blood. 2015;126:3132.
Clausen J. New approaches in graft versus host disease (GvHD) management. Memo. 2016;9(1):45–7.
Peled J, et al. The abundance of certain bacteria in the intestinal flora is associated with relapse after allogeneic hematopoietic stem cell transplantation. Blood. 2015;126:744.
Routy B, et al. Influence of prophylactic antibiotics aiming at gut decontamination on gastrointestinal graft-versus-host disease and overall survival following allogeneic haematopoietic stem cell transplantation. Blood. 2015;126:4319.
Atallah E, et al. Outcome of patients 65 years and older with myelodysplastic syndrome (MDS) receiving allogeneic hematopoietic stem cell transplantation compared to patients 55–64 years of age. Blood. 2015;126:193.
Attal M, et al. Autologous transplantation for multiple myeloma in the era of new drugs: a phase III study of the Intergroupe Francophone du Myelome (IFM/DFCI 2009 trial). Blood. 2015;126:391.
Cook G, et al. A salvage autologous stem cell transplant (ASCT2) induces superior overall survival following bortezomib-containing re-induction therapy for relapsed multiple myeloma (MM): results from the myeloma X (intensive) trial. Blood. 2015;126:394.
Maude SL, et al. Efficacy and safety of humanized chimeric antigen receptor (CAR)-modified T cells targeting CD19 in children with relapsed/ refractory ALL. Blood. 2015;126:683.
Curran KJ, et al. Multi-center clinical trial of CAR T cells in pediatric/young adult patients with relapsed B-cell ALL. Blood. 2015;126:2533.
Enblad G, et al. Third generation CD19-CAR T cells for relapsed and refractory lymphoma and leukemia report from the swedish phase I/IIa trial. Blood. 2015;126:1534.
Danhof S, et al. CAR-engineered T cells specific for the elotuzumab target SLAMF7 eliminate primary myeloma cells and confer selective fratricide of SLAMF7+ normal lymphocyte subsets. Blood. 2015;126:115.
Arcangeli S, et al. CAR-engineered T cells specific for the elotuzumab target SLAMF7 eliminate primary myeloma cells and confer selective fratricide of SLAMF7+ normal lymphocyte subsets. Blood. 2015;126:1359.
Kebriaei P, et al. Pre-emptive donor lymphocyte infusion with CD19-directed, CAR-modified T cells infused after allogeneic hematopoietic cell transplantation for patients with advanced CD19+ malignancies. Blood. 2015;126:862.
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Conflict of interest
J. Clausen declares that he has no competing interests.
Rights and permissions
About this article
Cite this article
Clausen, J. ASH 2015 – stem cell transplantation. memo 9, 136–138 (2016). https://doi.org/10.1007/s12254-016-0276-2
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s12254-016-0276-2