Abstract
Rare earth metals (REM) are a group of 17 chemical elements in the periodic table, namely scandium (Sc), yttrium (Y) and the lanthanides. In relation to atomic volume and geological behavior, the lanthanides are further subdivided into light, medium and heavy REM. They find many applications in the technological field; however, their impact on the human health is still conflicting and, for many aspects, unknown. During a research program carried on 113 cases of female breast cancer, immunohistochemically categorized in Her2-positive (29 cases), Her2-negative (57 cases) and triple negative (27 cases), aimed to evaluate the role of environmental particulate in carcinogenesis by elemental microanalysis, for the first time in literature we have detected a REM uptake, in detail europium (Eu), dysprosium (Dy) and praseodymium (Pr), inside the neoplastic cells belonging to a single triple negative breast cancer. Curiously, the woman affected by this form of malignancy had worked in the ceramic industry, a well-known source of REM, during her life, and she was the one and only patient of our series to be dedicated to this activity. The medical repercussions of our findings are here discussed: in fact, a REM detection in only 1 of 113 examined cases seems to exclude active roles in breast carcinogenesis and discloses new possibilities for therapeutic developments in triple negative breast cancer.
References
Connelly NG, Damhus T, Hartshorn RM, Hutton AT (2005) Nomenclature of inorganic chemistry: IUPAC recommendations. RSC Publishing, Cambridge
Gschneidner KA, Cappellen J (1987) 1787–1987 two hundred years of rare earths. North-Holland, Rare Earth Information Center
Haxel GB, Hedrick JB, Orris GJ (2002) Rare earth elements - critical resources for high technology. U.S. Geological Survey. http://pubs.usgs.gov/fs/2002/fs087-02/fs087-02.pdf. Accessed 20 November 2002
Zhang J, Chen Q, Wang N, Zhang J (2003) Levels and distribution of 15 rare earth elements in tumor and normal lung tissue from the patients with lung cancer. Wei Sheng Yan Jiu 32:423–426
Dai Y, Li J, Li J, Yu L, Dai G, Hu A et al (2002) Effects of rare earth compounds on growth and apoptosis of leukemic cell lines. In Vitro Cell Dev Biol Anim 38:373–375
Zhuang G, Zhou Y, Lu H, Lu W, Zhou M, Wang Y et al (1996) Concentration of rare earth elements, As, and Th in human brain and brain tumors, determined by neutron activation analysis. Biol Trace Elem Res 53:45–49
Roncati L, Barbolini G, Piacentini F, Piscioli F, Pusiol T, Maiorana A (2016) Prognostic factors for breast cancer: an immunomorphological update. Pathol Oncol Res 22:449–452
Gatti AM, Montanari S (2005) Risk assessment of microparticles and nanoparticles and human health. In: Nalwa HS (ed) Handbook of nanostructured biomaterials and their applications in nanobiotechnology. American Scientific Publishers, Portland, pp 347–369
Azimi G, Dhiman R, Kwon HM, Paxson AT, Varanasi KK (2013) Hydrophobicity of rare-earth oxide ceramics. Nat Mater 12:315–320
Shibata N, Pennycook SJ, Gosnell TR, Painter GS, Shelton WA, Becher PF (2004) Observation of rare-earth segregation in silicon nitride ceramics at subnanometre dimensions. Nature 428:730–733
Ji YJ, Xiao B, Wang ZH, Cui MZ, Lu YY (2000) The suppression effect of light rare earth elements on proliferation of two cancer cell lines. Biomed Environ Sci 13:287–292
Chen GJ, Wang ZG, Qiao X, Xu JY, Tian JL, Yan SP (2013) Synthesis, DNA binding, photo-induced DNA cleavage, cytotoxicity studies of a family of heavy rare earth complexes. J Inorg Biochem 127:39–45
Zhou J, Wang LF, Wang JY, Tang N (2001) Synthesis, characterization, antioxidative and antitumor activities of solid quercetin rare earth (III) complexes. J Inorg Biochem 83:41–48
Haley TJ, Komesu N, Colvin G, Koste L, Upham HC (1965) Pharmacology and toxicology of europium chloride. J Pharm Sci 54:643–645
Bruce DW, Hietbrink BE, Dubois KP (1963) The acute mammalian toxicity of rare earth nitrates and oxides. Toxicol Appl Pharmacol 5:750–759
Giri S, Karakoti A, Graham RP, Maguire JL, Reilly CM, Seal S et al (2013) Nanoceria: a rare-earth nanoparticle as a novel anti-angiogenic therapeutic agent in ovarian cancer. PLoS One 8:e54578
Roncati L, Barbolini G, Gatti AM, Pusiol T, Piscioli F, Maiorana A (2016) The uncontrolled sialylation is related to chemoresistant metastatic breast cancer. Pathol Oncol Res 22:869–873
Foulkes WD, Smith IE, Reis-Filho JS (2010) Triple-negative breast cancer. N Engl J Med 363:1938–1948
Hudis CA, Gianni L (2011) Triple-negative breast cancer: an unmet medical need. Oncologist 16:1–11
Basu S, Chen W, Tchou J, Mavi A, Cermik T, Czerniecki B et al (2008) Comparison of triple-negative and estrogen receptor-positive/progesterone receptor-positive/HER2-negative breast carcinoma using quantitative fluorine-18 fluorodeoxyglucose/positron emission tomography imaging parameters: a potentially useful method for disease characterization. Cancer 112:995–1000
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The authors acknowledge the Interdepartmental Great Instrument Center (CIGS) of the Modena and Reggio Emilia University (UNIMORE) and the Nanodiagnostics Srl Laboratory of Modena for the technological support.
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This study was funded by the Italian Research Program of Emilia Romagna Region for the University of Modena and Reggio Emilia (CUP E35E09000880002).
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Roncati, L., Gatti, A.M., Barbolini, G. et al. In Vivo Uptake of Rare Earth Metals by Triple-Negative Breast Cancer Cells. Pathol. Oncol. Res. 24, 161–165 (2018). https://doi.org/10.1007/s12253-017-0209-3
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DOI: https://doi.org/10.1007/s12253-017-0209-3