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Interleukin-1 Gene Cluster Polymorphisms and its Haplotypes may Predict the Risk to Develop Cervical Cancer in Tunisia

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Pathology & Oncology Research

Abstract

Our study aimed to evaluate the association between IL-1α (4845 G/T), IL-1β (-511C/T) and IL-1RN (VNTR) polymorphisms and risk of cervical cancer. This case-control study investigates three polymorphisms in 130 patients and 260 controls by PCR-restriction fragment length polymorphism (RFLP). The IL-1RN (VNTR) A1/A3 genotype appear as a cervical cancer risk factor (p = 0.048; OR = 2.92; 95 % CI = 1.00–8.74), moreover, the L/2* decreased the risk (p = 0.011; OR = 0.47; 95 % CI = 0.25–0.88) and may be a protective factor against this pathology. Stratified analysis according to the FIGO stage subgroup revealed that the IL-1β-511 T/T genotype and T allele may be a protective factors against cervical cancer development for patients with early stage (p = 0.030; OR = 0.46; 95 % CI = 0.22–0.96) (p = 0.020; OR = 0.68; 95 % CI = 0.48–0.97). However, for the patients with advanced FIGO stage, IL-1RN-VNTR L/2* genotype appear as a protective factor for this pathology (p = 0.023; OR = 0.29; 95 % CI = 0.08–0.99). The (G-T-L) haplotype showed a significant decreased frequency in cervical cancer patients as compared to controls (p = 0.032; OR = 0.53; 95 % CI = 0.29–0.95). In contrast, the (T-T-2*) combination appear a risk factor for the development of cervical cancer (p = 0.018; OR = 1.57; 95 % CI = 1.07–2.30). Our study suggested that IL1 cluster polymorphisms and haplotypes may be a genetic risk factor for cervical cancer.

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Acknowledgments

We thank all blood donors who participated in the present study.

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Authors and Affiliations

  1. Faculty of Sciences of Tunis, Laboratory of Micro-Organisms and Active Biomolecules, El Manar University, 2092 El MANAR I, Tunis, 1092, Tunisia

    Sabrina Zidi, Ikram Sghaier, Amira Benahmed & Besma Yacoubi-Loueslati

  2. CHU HABIB BOURGUIBA Sfax, Sfax, Tunisia

    Ferjeni Zouidi

  3. Research Unit of Hematological and Autoimmune Diseases, Faculty of Pharmacy, University of Monastir, Monastir, Tunisia

    Mouna Stayoussef

  4. Laboratory of Immunology, Military Hospital of Tunis, Tunis, Tunisia

    Radhia Kochkar & Ezzedine Gazouani

  5. Salah Azeiz Oncology Institute, Tunis, Tunisia

    Amel Mezlini

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  1. Sabrina Zidi
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Correspondence to Sabrina Zidi.

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Zidi, S., Sghaier, I., Zouidi, F. et al. Interleukin-1 Gene Cluster Polymorphisms and its Haplotypes may Predict the Risk to Develop Cervical Cancer in Tunisia. Pathol. Oncol. Res. 21, 1101–1107 (2015). https://doi.org/10.1007/s12253-015-9941-8

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  • DOI: https://doi.org/10.1007/s12253-015-9941-8

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