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WWP2: A Multifunctional Ubiquitin Ligase Gene

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Pathology & Oncology Research

Abstract

The ubiquitin-proteasome system plays an important role in various celluar processes. WWP2, a recently identified ubiquitin E3 ligase, has been proved a multifunctional gene by degradation a series of targets via ubiquitin-dependent proteasome system, including PETN, Smads, Oct4, EGR2, TIRF and so. Hereafter, we reviewed the recent research process about the function of WWP2.

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Acknowledgments

This work was supported Major Cultivated Project of Youth Science and Technology Fund in Sichuan North Medical College (serial number: CBY11-A-ZP15).

Disclosure Statement

No competing financial interests exit.

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Authors and Affiliations

  1. Department of Pathophysiology, Sichuan North Medical College, Nanchong, 637100, People’s Republic of China

    Wei Chen

  2. Department of General Surgery, The Seventh People’s Hospital of Chengdu, Chengdu, 610041, People’s Republic of China

    Xiaofei Jiang

  3. Department of Respiratory Diseases, First Affiliated Hospital, Kunming Medical University, Kunming, 650032, People’s Republic of China

    Zhuang Luo

  4. Department of Respiratory Medicine, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China

    Zhuang Luo

Authors
  1. Wei Chen
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  2. Xiaofei Jiang
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  3. Zhuang Luo
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Corresponding author

Correspondence to Zhuang Luo.

Additional information

Wei Chen and Xiaofei Jiang contributed equally to this work

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Chen, W., Jiang, X. & Luo, Z. WWP2: A Multifunctional Ubiquitin Ligase Gene. Pathol. Oncol. Res. 20, 799–803 (2014). https://doi.org/10.1007/s12253-014-9838-y

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  • DOI: https://doi.org/10.1007/s12253-014-9838-y

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