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Common Infections May Lead to Alzheimer’s Disease

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Virologica Sinica

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References

  • Bourgade K, Garneau H, Giroux G, Le Page AY, Bocti C, Dupuis G, Frost EH, Fulop T Jr (2015) Beta-amyloid peptides display protective activity against the human Alzheimer’s disease-associated herpes simplex virus-1. Biogerontology 16:85–98

    Article  CAS  Google Scholar 

  • Jha HC, Mehta D, Lu J, El-Naccache D, Shukla SK, Kovacsics C, Kolson D, Robertson ES (2015) Gammaherpesvirus infection of human neuronal cells. MBio 6:e01815–01844

    Article  Google Scholar 

  • Kleinschmidt-DeMasters BK, Gilden DH (2001) The expanding spectrum of herpesvirus infections of the nervous system. Brain Pathol 11:440–451

    Article  CAS  Google Scholar 

  • Komaroff AL, Boeckh M, Eliason E, Phan T, Kaufer BB (2018) Summary of the 10th international conference on human herpesviruses-6 and -7 (HHV-6A, -6B, and HHV-7). J Med Virol 90:625–630

    Article  Google Scholar 

  • Kumar DK, Choi SH, Washicosky KJ, Eimer WA, Tucker S, Ghofrani J, Lefkowitz A, McColl G, Goldstein LE, Tanzi RE, Moir RD (2016) Amyloid-beta peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease. Sci Transl Med 8:340ra372

    Article  Google Scholar 

  • Lambert JC, Ibrahim-Verbaas CA, Harold D, Naj AC, Sims R, Bellenguez C, DeStafano AL, Bis JC, Beecham GW, Grenier-Boley B et al (2013) Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer’s disease. Nat Genet 45:1452–1458

    Article  CAS  Google Scholar 

  • Mawanda F, Wallace R (2013) Can infections cause Alzheimer’s disease? Epidemiol Rev 35:161–180

    Article  Google Scholar 

  • Prusty BK, Gulve N, Rasa S, Murovska M, Hernandez PC, Ablashi DV (2017) Possible chromosomal and germline integration of human herpesvirus 7. J Gen Virol 98:266–274

    Article  CAS  Google Scholar 

  • Readhead B, Haure-Mirande JV, Funk CC, Richards MA, Shannon P, Haroutunian V, Sano M, Liang WS, Beckmann ND, Price ND, Reiman EM, Schadt EE, Ehrlich ME, Gandy S, Dudley JT (2018) Multiscale analysis of independent Alzheimer’s Cohorts finds disruption of molecular, genetic, and clinical networks by human herpesvirus. Neuron 99(64–82):e7

    Google Scholar 

  • Shu M, Du T, Zhou G, Roizman B (2015) Role of activating transcription factor 3 in the synthesis of latency-associated transcript and maintenance of herpes simplex virus 1 in latent state in ganglia. Proc Natl Acad Sci U S A 112:E5420–E5426

    Article  CAS  Google Scholar 

  • Sjogren T, Sjogren H, Lindgren AG (1952) Morbus Alzheimer and Morbus Pick; a genetic, clinical and patho-anatomical study. Acta Psychiatr Neurol Scand Suppl 82:1–152

    CAS  PubMed  Google Scholar 

  • Tanaka-Taya K, Sashihara J, Kurahashi H, Amo K, Miyagawa H, Kondo K, Okada S, Yamanishi K (2004) Human herpesvirus 6 (HHV-6) is transmitted from parent to child in an integrated form and characterization of cases with chromosomally integrated HHV-6 DNA. J Med Virol 73:465–473

    Article  Google Scholar 

  • van den Pol AN (2009) Viral infection leading to brain dysfunction: more prevalent than appreciated? Neuron 64:17–20

    Article  Google Scholar 

  • Zhu M, Allard JS, Zhang Y, Perez E, Spangler EL, Becker KG, Rapp PR (2014) Age-related brain expression and regulation of the chemokine CCL4/MIP-1beta in APP/PS1 double-transgenic mice. J Neuropathol Exp Neurol 73:362–374

    Article  CAS  Google Scholar 

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Acknowledgements

We thank all members in the lab for critical reading and discussion. This work was supported by the National Key Research and Development Program of China (2016YFC1200400). QC is a scholar of New Century Excellent Talents in University of China.

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Author notes

  1. Yuyan Wang, Ling Ding and Qing Zhu have equally contributed to this work.

Authors and Affiliations

  1. MOE & MOH Key Laboratory of Medical Molecular Virology, School of Basic Medicine, Shanghai Medical College, Fudan University, Shanghai, 200032, China

    Yuyan Wang, Ling Ding, Qing Zhu, Minfeng Shu & Qiliang Cai

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  1. Yuyan Wang
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  2. Ling Ding
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  3. Qing Zhu
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  4. Minfeng Shu
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Corresponding authors

Correspondence to Minfeng Shu or Qiliang Cai.

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The authors declare that they have no conflict of interest.

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This article does not contain any studies with human or animal subjects performed by any of the authors.

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Wang, Y., Ding, L., Zhu, Q. et al. Common Infections May Lead to Alzheimer’s Disease. Virol. Sin. 33, 456–458 (2018). https://doi.org/10.1007/s12250-018-0049-7

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  • DOI: https://doi.org/10.1007/s12250-018-0049-7

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